ArticleProceedings of the National Academy of Sciences of the United States of America2013
Mechanism of proton-coupled quinone reduction in Photosystem II.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed, 161 citations in OpenAlex.
- Effects of high light and elevated temperature on the structure of photosystem II isolated from Arabidopsis thaliana.Photosynthesis research · 2026Article
- The contribution of thePhotosynthesis research · 2026Article
- The structure of intact and active Photosystem II from Arabidopsis thaliana at 2.44 Å resolution.The New phytologist · 2026Article
- Cryo-EM structure of photosystem II supercomplex from a green microalga with extreme phototolerance.Nature communications · 2026Article
- Current perspectives on proton and electron transfer pathways in photosystem II water oxidation.Plant & cell physiology · 2025Review
- Photosystem II: commonality and diversity with emphasis on the extrinsic subunits.Plant & cell physiology · 2025Review
- Photosystem II: Probing Protons and Breaking Barriers.Biochemistry · 2025Review
- Depletion reveals role of bicarbonate in the photosynthetic electron transport chain ofFrontiers in plant science · 2025Article
- Conformational control over proton-coupled electron transfer in metalloenzymes.Nature reviews. Chemistry · 2024Review
- Absence of a link between stabilized charge-separated state and structural changes proposed from crystal structures of a photosynthetic reaction center.Communications chemistry · 2024Article
- Energetics of the H-Bond Network inBiochemistry · 2024Article
- Iron mobilization from intact ferritin: effect of differential redox activity of quinone derivatives with NADH/OJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024Article
- Exploring the Deprotonation Process during Incorporation of a Ligand Water Molecule at the Dangling Mn Site in Photosystem II.The journal of physical chemistry. B · 2024Article
- Rotaxane-Functionalized Dyes for Charge-Rectification in p-Type Photoelectrochemical Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Role of hydrogen-bond networks on the donor side of photosynthetic reaction centers from purple bacteria.Biophysical reviews · 2023Review
- Mechanism of Asparagine-Mediated Proton Transfer in Photosynthetic Reaction Centers.Biochemistry · 2023Article
- Photocatalytic CONature communications · 2023Article
- Functional Water Networks in Fully Hydrated Photosystem II.Journal of the American Chemical Society · 2022Article
- Electron Transfer Route between Quinones in Type-II Reaction Centers.The journal of physical chemistry. B · 2022Article
- Release of a Proton and Formation of a Low-Barrier Hydrogen Bond between Tyrosine D and D2-His189 in Photosystem II.ACS physical chemistry Au · 2022Article
4 more citing papers are in PubMed but not listed here.
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3 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Photosystem II uses light to drive water oxidation and plastoquinone (PQ) reduction. PQ reduction involves two PQ cofactors, Q(A) and Q(B), working in series. Q(A) is a one-electron carrier, whereas Q(B) undergoes sequential reduction and protonation to form Q(B)H(2). Q(B)H(2) exchanges with PQ from the pool in the membrane. Based on the atomic coordinates of the Photosystem II crystal structure, we analyzed the proton transfer (PT) energetics adopting a quantum mechanical/molecular mechanical approach. The potential-energy profile suggests that the initial PT to Q(B)(•-) occurs from the protonated, D1-His252 to Q(B)(•)(-) via D1-Ser264. The second PT is likely to occur from D1-His215 to Q(B)H(-) via an H-bond with an energy profile with a single well, resulting in the formation of Q(B)H(2) and the D1-His215 anion. The pathway for reprotonation of D1-His215(-) may involve bicarbonate, D1-Tyr246 and water in the Q(B) site. Formate ligation to Fe(2+) did not significantly affect the protonation of reduced Q(B), suggesting that formate inhibits Q(B)H(2) release rather than its formation. The presence of carbonate rather than bicarbonate seems unlikely because the calculations showed that this greatly perturbed the potential of the nonheme iron, stabilizing the Fe(3+) state in the presence of Q(B)(•-), a situation not encountered experimentally. H-bonding from D1-Tyr246 and D2-Tyr244 to the bicarbonate ligand of the nonheme iron contributes to the stability of the semiquinones. A detailed mechanistic model for Q(B) reduction is presented.
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