ArticleProceedings of the National Academy of Sciences of the United States of America2013
Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
- A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons.Frontiers in pharmacology · 2025Article
- Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants.Cellular and molecular life sciences : CMLS · 2024Article
- Developmental Impairments of Synaptic Refinement in the Thalamus of a Mouse Model of Fragile X Syndrome.Neuroscience bulletin · 2024Article
- Self-Regulatory Neuronal Mechanisms and Long-Term Challenges in Schizophrenia Treatment.Brain sciences · 2023Review
- Cortical inhibitory but not excitatory synaptic transmission and circuit refinement are altered after the deletion of NMDA receptors during early development.Scientific reports · 2023Article
- The Implication of Glial Metabotropic Glutamate Receptors in Alzheimer's Disease.Current neuropharmacology · 2023Review
- Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both?Biological psychiatry · 2022Review
- Developmental Shifts in Amygdala Activity during a High Social Drive State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Consequences of NMDA receptor deficiency can be rescued in the adult brain.Molecular psychiatry · 2021Article
- Visual cortical plasticity and the risk for psychosis: An interim analysis of the North American Prodrome Longitudinal Study.Schizophrenia research · 2021Article
- Article
- De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases.Human mutation · 2019Article
- N-terminal alternative splicing of GluN1 regulates the maturation of excitatory synapses and seizure susceptibility.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity.Molecular neuropsychiatry · 2019Review
- The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits.Scientific reports · 2019Article
- Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons.Nature communications · 2017Article
- Mapping the Consequences of Impaired Synaptic Plasticity in Schizophrenia through Development: An Integrative Model for Diverse Clinical Features.Trends in cognitive sciences · 2017Review
- Abnormal sensory experiences, synaesthesia, and neurodevelopmental disorders.Journal of autism and developmental disorders · 2017Article
- NMDA Receptors Regulate the Development of Neuronal Intrinsic Excitability through Cell-Autonomous Mechanisms.Frontiers in cellular neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neurons in the brains of newborns are usually connected with many other neurons through weak synapses. This early pattern of connectivity is refined through pruning of many immature connections and strengthening of the remaining ones. NMDA receptors (NMDARs) are essential for the development of excitatory synapses, but their role in synaptic refinement is controversial. Although chronic application of blockers or global knockdown of NMDARs disrupts developmental refinement in many parts of the brain, the ubiquitous presence of NMDARs makes it difficult to dissociate direct effects from indirect ones. We addressed this question in the thalamus by using genetic mosaic deletion of NMDARs. We demonstrate that pruning and strengthening of immature synapses are blocked in neurons without NMDARs, but occur normally in neighboring neurons with NMDARs. Our data support a model in which activation of NMDARs in postsynaptic neurons initiates synaptic refinement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.