ArticleProceedings of the National Academy of Sciences of the United States of America2013
Long-range protein-water dynamics in hyperactive insect antifreeze proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 250 citations in OpenAlex.
- Peptides display multilayered hydration shell substructures dictated by sequence-specific surface chemistry.Nature communications · 2026Article
- Water Under Molecular Crowding: From Femtosecond H-Bond Networks Dynamics to Biological Function.Sub-cellular biochemistry · 2026Review
- Structure and Dynamics of Water in Polysaccharide (Alginate) Solutions and Gels Explained by the Core-Shell Model.Biomacromolecules · 2024Article
- Probing the structure of water in individual living cells.Nature communications · 2024Article
- Water determines the intramolecular dynamics of proteins. En example of bovine serum albumin.Frontiers in chemistry · 2024Article
- Terahertz spectroscopy as a method for investigation of hydration shells of biomolecules.Biophysical reviews · 2023Review
- When Phased without Water: Biophysics of Cellular Desiccation, from Biomolecules to Condensates.Chemical reviews · 2023Review
- De novo designed ice-binding proteins from twist-constrained helices.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spatial Layouts of Low-Entropy Hydration Shells Guide Protein Binding.Global challenges (Hoboken, NJ) · 2023Article
- Detecting the First Hydration Shell Structure around Biomolecules at Interfaces.ACS central science · 2022Article
- Implementation of Telescoping Boxes in Adaptive Steered Molecular Dynamics.Journal of chemical theory and computation · 2022Article
- Ice Recrystallization Inhibition Is Insufficient to Explain Cryopreservation Abilities of Antifreeze Proteins.Biomacromolecules · 2022Article
- Complete inhibition of a polyol nucleation by a micromolar biopolymer additive.Cell reports. Physical science · 2022Article
- The origin and impact of bound water around intrinsically disordered proteins.Biophysical journal · 2022Article
- Structural diversity of marine anti-freezing proteins, properties and potential applications: a review.Bioresources and bioprocessing · 2022Review
- High Water Density at Non-Ice-Binding Surfaces Contributes to the Hyperactivity of Antifreeze Proteins.The journal of physical chemistry letters · 2021Article
- Analysis of the Sequence Characteristics of Antifreeze Protein.Life (Basel, Switzerland) · 2021Article
- Characterization of microbial antifreeze protein with intermediate activity suggests that a bound-water network is essential for hyperactivity.Scientific reports · 2021Article
- On the existence of soliton-like collective modes in liquid water at the viscoelastic crossover.Scientific reports · 2021Article
- Locating and Navigating Energy Transport Networks in Proteins.Methods in molecular biology (Clifton, N.J.) · 2021Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antifreeze proteins (AFPs) are specific proteins that are able to lower the freezing point of aqueous solutions relative to the melting point. Hyperactive AFPs, identified in insects, have an especially high ability to depress the freezing point by far exceeding the abilities of other AFPs. In previous studies, we postulated that the activity of AFPs can be attributed to two distinct molecular mechanisms: (i) short-range direct interaction of the protein surface with the growing ice face and (ii) long-range interaction by protein-induced water dynamics extending up to 20 Å from the protein surface. In the present paper, we combine terahertz spectroscopy and molecular simulations to prove that long-range protein-water interactions make essential contributions to the high antifreeze activity of insect AFPs from the beetle Dendroides canadensis. We also support our hypothesis by studying the effect of the addition of the osmolyte sodium citrate.
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