ReviewJournal of geriatric psychiatry and neurology2012
Pain in people with Alzheimer disease: potential applications for psychophysical and neurophysiological research.
Review in Journal of geriatric psychiatry and neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Experimentally evoked pain in Alzheimer's disease.Journal of the American Association of Nurse Practitioners · 2021Pooled it
- Association between pain, neuropsychiatric symptoms, and physical function in dementia: a systematic review and meta-analysis.BMC geriatrics · 2015Pooled it
- Orofacial pain and dementia: a brief narrative review of associations, putative mechanisms, and relevant clinical considerations.Odontology · 2026Review
- Pain in Alzheimer's Disease: Disrupted Multilevel Integration of Nociception, Affective Processing and Clinical Expression Across Clinical and Preclinical Evidence.Life (Basel, Switzerland) · 2026Review
- Mechanisms and Characteristics of Chronic Pain in Alzheimer's Disease: A Narrative Review.Current medicinal chemistry · 2026Review
- Sex- and APOE Genotype-Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme LPCAT2.Aging cell · 2025Article
- A conceptual model for assessing the risk of unidentified pain.The journal of pain · 2025Article
- Exercise-Based Pain Interventions for People with Dementia Using a Biopsychosocial-Environmental (BPSE) Model.Current geriatrics reports · 2025Review
- Pain management inequities by demographic and geriatric-related variables in older adult inpatients.Journal of the American Geriatrics Society · 2024Article
- Association between chronic pain and dementia: a systematic review and meta-analysis.European journal of ageing · 2024Review
- Psychophysics of Pain: A Methodological Introduction.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- Development of a spontaneous pain indicator based on brain cellular calcium using deep learning.Experimental & molecular medicine · 2022Article
- A Cross-Sectional Study of Pain Sensitivity and Unpleasantness in People with Vascular Dementia.Pain medicine (Malden, Mass.) · 2022Article
- Treating the most vulnerable: A discursive review of experimental pain in Alzheimer's disease.Nursing open · 2022Review
- Increased pain unpleasantness and pain-related fMRI activation in the periaqueductal gray in Alzheimer's disease.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Narrative Review of Sensory Changes as a Biomarker for Alzheimer's Disease.Biological research for nursing · 2021Review
- Determining the impact of age and sex on the psychophysical and neurophysiological response to thermal pain across the adult lifespan.Journal of advanced nursing · 2021Article
- Policy Implications for Pain in Advanced Alzheimer's Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Article
- Pain and Associated Neuropsychiatric Symptoms in Patients Suffering from Dementia: Challenges at Different Levels and Proposal of a Conceptual Framework.Journal of Alzheimer's disease : JAD · 2021Review
- Are Chronic Pain Patients with Dementia Being Undermedicated?Journal of pain research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pain management in people with dementia is a critical problem. Recently, psychophysical and neuroimaging techniques have been used to extend our understanding of pain processing in the brain as well as to identify structural and functional changes in Alzheimer disease (AD). But interpreting the complex relationship between AD pathology, brain activation, and pain reports is challenging. This review proposes a conceptual framework for designing and interpreting psychophysical and neuroimaging studies of pain processing in people with AD. Previous human studies describe the lateral (sensory) and medial (affective) pain networks. Although the majority of the literature on pain supports the lateral and medial networks, some evidence supports an additional rostral pain network, which is believed to function in the production of pain behaviors. The sensory perception of pain as assessed through verbal report and behavioral display may be altered in AD. In addition, neural circuits mediating pain perception and behavioral expression may be hyperactive or underactive, depending on the brain region involved, stage of the disease, and type of pain (acute experimental stimuli or chronic medical conditions). People with worsening AD may therefore experience pain but be unable to indicate pain through verbal or behavioral reports, leaving them at great risk of experiencing untreated pain. Psychophysical (verbal or behavioral) and neurophysiological (brain activation) approaches can potentially address gaps in our knowledge of pain processing in AD by revealing the relationship between neural processes and verbal and behavioral outcomes in the presence of acute or chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.