SynthesisNeuroImage2013
Age-related differences in iron content of subcortical nuclei observed in vivo: a meta-analysis.
Synthesis in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Globus Pallidus Iron Relates to Cognitive Impairment in Alzheimer's Disease: Evidence From MRI-Based Meta-Analysis.Annals of the New York Academy of Sciences · 2026Pooled it
- Meta-analysis of brain iron levels of Parkinson's disease patients determined by postmortem and MRI measurements.Scientific reports · 2016Pooled it
- Population-based Brain Templates for Ultra-Low-Field MRI.Scientific data · 2026Article
- Regulation of brain iron homeostasis and its influence on cognitive function.European radiology · 2026Article
- The role of quantitative susceptibility mapping in dementia with Lewy Bodies.NeuroImage. Clinical · 2026Article
- Aging of gray matter microstructure: A brain-wide characterization of age group differences using NODDI.Neurobiology of aging · 2025Article
- Article
- Article
- Parkinson's disease and metabolic disorders, understanding their shared co-morbidity through the autonomic nervous system.Advances in genetics · 2025Review
- Automated segmentation of midbrain nuclei using deep learning and multisequence MRI: A longitudinal study on iron accumulation with age.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Review
- Moderating role of physical activity on hippocampal iron deposition and memory outcomes in typically aging older adults.Neurobiology of aging · 2023Article
- Mixed methodology in human brain research: integrating MRI and histology.Brain structure & function · 2023Review
- Dysfunction of the hypothalamic-pituitary adrenal axis and its influence on aging: the role of the hypothalamus.Scientific reports · 2023Article
- High cortical iron is associated with the disruption of white matter tracts supporting cognitive function in healthy older adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- What Do Randomized Controlled Trials Inform Us About Potential Disease-Modifying Strategies for Parkinson's Disease?Neuromolecular medicine · 2023Review
- DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson's Disease.Journal of Parkinson's disease · 2023Review
- Susceptibility networks reveal independent patterns of brain iron abnormalities in multiple sclerosis.NeuroImage · 2022Article
- Quantifying Brain Iron in Hereditary Hemochromatosis Using R2* and Susceptibility Mapping.AJNR. American journal of neuroradiology · 2022Article
- Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention.Frontiers in neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Accumulation of non-heme iron in the brain has been proposed as a biomarker of the progressive neuroanatomical and cognitive declines in healthy adult aging. Postmortem studies indicate that iron content and lifespan differences therein are regionally specific, with a predilection for the basal ganglia. However, the reported in vivo estimates of adult age differences in iron content within subcortical nuclei are highly variable. We present a meta-analysis of 20 in vivo magnetic resonance imaging (MRI) studies that estimated iron content in the caudate nucleus, globus pallidus, putamen, red nucleus, and substantia nigra. The results of the analyses support a robust association between advanced age and high iron content in the substantia nigra and striatum, with a smaller effect noted in the globus pallidus. The magnitude of age differences in estimated iron content of the caudate nucleus and putamen partially depended on the method of estimation, but not on the type of design (continuous age vs. extreme age groups).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.