Evidence map›Paper›PMID 23277050›Full record

ReviewFrontiers in bioscience (Scholar edition)2013

Presynaptic dopamine modulation by stimulant self-administration.

Rodrigo A Espana, Sara R Jones

Open access · bronzeAbstract readReview
In one paragraph

Review in Frontiers in bioscience (Scholar edition), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Dopamine Pharmacodynamics: New Insights.International journal of molecular sciences · 2024
    Review
  3. Effects of naltrexone on amphetamine choice in rhesus monkeys and rats.Experimental and clinical psychopharmacology · 2023
    Article
  4. Article
  5. Review
  6. Review
  7. Dopamine Increases CD14Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017
    Article
  8. Article
  9. mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  10. Article
  11. Baths salts, spice, and related designer drugs: the science behind the headlines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Review
  12. Article
  13. The infralimbic cortex bidirectionally modulates mesolimbic dopamine neuron activity via distinct neural pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
  14. Review
  15. Neuropharmacology of Synthetic Cathinones.Handbook of experimental pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rodrigo A EspanaDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Sara R Jones
Wake Forest University · US

Funding

TROPANE EVALUATION AND GENERAL SCIENTIFIC SERVICES COREP50DA006634 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HOWLETT, ALLYN C · 1991 to 2019
$30.8M
Dopamine Transporter Changes Following Cocaine Self-AdministrationR01DA021325 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2007 to 2011
$1.4M
Methylphenidate, Serotonin and Dopamine InteractionsR01DA030161 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2010 to 2014
$1.4M
Hypocretin/Orexin Modulation of Reward and Addiction ProcessesK01DA025279 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPAÑA, RODRIGO A. · 2008 to 2012
$771k
Voltammetry in Freely Moving MiceR21DA018815 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA R · 2004 to 2005
$287k
NIDA NIH HHS K01 DA025279NIDA NIH HHS P50 DA006634NIDA NIH HHS P50 DA06634NIDA NIH HHS R01 DA021325NIDA NIH HHS R01 DA030161NIDA NIH HHS R21 DA018815
6 · The paper itself

Abstract

The mesolimbic dopamine system is an essential participant in the initiation and modulation of various forms of goal-directed behavior, including drug reinforcement and addiction processes. Dopamine neurotransmission is increased by acute administration of all drugs of abuse, including the stimulants cocaine and amphetamine. Chronic exposure to these drugs via voluntary self-administration provides a model of stimulant abuse that is useful in evaluating potential behavioral and neurochemical adaptations that occur during addiction. This review describes commonly used methodologies to measure dopamine and baseline parameters of presynaptic dopamine regulation, including exocytotic release and reuptake through the dopamine transporter in the nucleus accumbens core, as well as dramatic adaptations in dopamine neurotransmission and drug sensitivity that occur with acute non-contingent and chronic, contingent self-administration of cocaine and amphetamine.

Indexed as

AnimalsCentral Nervous System StimulantsDopamineDopamine Plasma Membrane Transport ProteinsHumansIllicit DrugsLimbic SystemPresynaptic TerminalsSelf AdministrationSynaptic TransmissionCentral Nervous System StimulantsDopamineDopamine Plasma Membrane Transport ProteinsIllicit Drugs

Identifiers

PMID23277050
PMCPMC3733372
OpenAlexW2151866018

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.