Evidence map›Paper›PMID 23277041›Full record

ReviewFrontiers in bioscience (Scholar edition)2013

Protective cardiovascular and renal actions of vitamin D and estrogen.

Pandu R Gangula, Yuan-Lin Dong, Ayman Al-Hendy, Gloria Richard-Davis, Valerie Montgomery-Rice, Georges Haddad, Rihcard Millis, Susanne B Nicholas, Diane Moseberry

Open access · greenAbstract readReview
In one paragraph

Review in Frontiers in bioscience (Scholar edition), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
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  4. Review
  5. Article
  6. Role of Sex Hormones in Prevalent Kidney Diseases.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Pandu R GangulaDepartments of Physiology, Meharry Medical College, Nashville, TN 37208, USA. pgangula@mmc.edu
Yuan-Lin Dong
Ayman Al-Hendy
Gloria Richard-Davis
Valerie Montgomery-Rice
Georges Haddad
Rihcard Millis
Susanne B Nicholas
Diane Moseberry
Meharry Medical College · US

Funding

Workshop for Junior Biostatisticians in Health ResearchU54MD007598 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI Ali Andalibi, Jose A Torres-Ruiz · 2012 to 2026
$60.0M
Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
The Howard University SCORE Program Supplemental GrantS06GM008016 · NIGMS · HOWARD UNIVERSITY · PI LITTLETON, GEORGE K · 1989 to 2009
$16.1M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
VITAMIN D STIMULATES CARDIAC DIFFERENTIATIONU54RR026138 · NCRR · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI NORRIS, KEITH C · 2009 to 2011
$14.0M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54RR026140 · NCRR · MEHARRY MEDICAL COLLEGE · PI GOODWIN, JEFFREY SHAWN · 2009 to 2011
$12.9M
Nitric Oxide and gastric motility in female diabeticsR21DK076704 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GANGULA, PANDU R · 2008 to 2010
$501k
MECHANISMS OF ALCOHOL-INDUCED CARDIOMYOPATHY.R15AA019816 · NIAAA · HOWARD UNIVERSITY · PI HADDAD, GEORGES E. · 2011 to 2011
$442k
NCRR NIH HHS 1 U54RR026138NCRR NIH HHS 1 U54RR026140-01NCRR NIH HHS U54 RR026138NCRR NIH HHS U54 RR026140NIAAA NIH HHS R15 AA019816NIDDK NIH HHS R21 DK076704NIGMS NIH HHS GM08016-38NIGMS NIH HHS S06 GM008016NIMHD NIH HHS G12 MD007597NIMHD NIH HHS U54 MD007593NIMHD NIH HHS U54 MD007598
6 · The paper itself

Abstract

Both basic science and clinical studies support the concept that vitamin D deficiency is involved in the pathogenesis of cardiovascular and renal diseases through its association with diabetes, obesity, and hypertension. Understanding the underlying mechanisms may provide a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases. This review explores the effect of vitamin D deficiency in the development of cardiovascular and renal diseases, and the role of vitamin D supplementation on cardiovascular outcomes. In addition, it highlights the importance of vitamin D intake for the prevention of adverse long-term health consequences, and in ways to facilitate the management of cardiovascular disease. This is particularly true for African American and postmenopausal women, who are at added risk for cardiovascular disease. We suggest that the negative cardiovascular effects of low vitamin D in postmenopausal women could be improved by a combined treatment of vitamin D and sex steroids acting through endothelium-dependent and/or -independent mechanisms, resulting in the generation of nitric oxide and calcitonin gene-related peptide (CGRP).

Indexed as

AnimalsCardiovascular DiseasesEstrogensHumansKidney DiseasesVitamin DVitamin D DeficiencyEstrogensVitamin D

Identifiers

PMID23277041
PMCPMC3673780
OpenAlexW2092309059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.