ArticleFrontiers in bioscience (Elite edition)2013
Gestational protein restriction affects trophoblast differentiation.
Article in Frontiers in bioscience (Elite edition), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring.Human molecular genetics · 2021Article
- Intrauterine growth restriction: screening and diagnosis using animal models.Animal reproduction · 2020Article
- Near to One's Heart: The Intimate Relationship Between the Placenta and Fetal Heart.Frontiers in physiology · 2018Review
- Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.The Journal of physiology · 2017Review
- Gestational protein restriction alters cell proliferation in rat placenta.Journal of molecular histology · 2016Article
- The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport.Genes & nutrition · 2016Article
- The Programming Power of the Placenta.Frontiers in physiology · 2016Review
- Adrenomedullin promotes rat trophoblast stem cell differentiation.Biology of reproduction · 2014Article
- Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia.Pediatric surgery international · 2014Article
- Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy.Journal of molecular histology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Whether and how gestational protein restriction (PR) affects placental development and function remain unknown. To test the hypothesis that PR can affect trophoblast differentiation in mid-and late pregnancy, rats were fed a 20% or an isocaloric 6% protein diet from Day 1 to 14 or 18 of pregnancy and effects of PR on trophoblast differentiation were determined by changes in expressions of marker gene(s) for trophoblast lineages. At Day 18 of pregnancy, PR increased expressions of Esrrb, Id1 andId2 (trophoblast stem cell markers), decreased expressions of Ascl2 (spongiotrophblast cell marker) and Prl2c1 (trophoblast giant cell marker), but did not alter expressions of Gjb3 and Pcdh12(glycogen cell markers) in the junctional zone (JZ). In the labyrinth zone (LZ), PR did not change expressions of Prl2b1 (trophoblast giant cell marker), Gcm1 and Syna (syncytiotrophoblast cell markers), but decrease expression of Ctsq (sinusoidal trophoblast giant cell marker). These results indicate that PR impairs the differentiation of trophoblast stem cell into spongiotrophoblast and trophoblast giant cells in JZ, and formation of sinusoidal trophoblast giant cells in LZ.
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Registered trials
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