ArticleFrontiers in bioscience (Landmark edition)2013
Homocysteine induces inflammatory transcriptional signaling in monocytes.
Article in Frontiers in bioscience (Landmark edition), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Using Machine Learning to Detect Factors That Affect Homocysteine in Healthy Elderly Taiwanese Men.Biomedicines · 2025Article
- Association Between Plasma Homocysteine, Folate, Vitamin B12 Levels, and Metabolic Dysfunction Indices in Elderly with Arterial Stiffness.Journal of clinical medicine · 2025Article
- Steroids and One-Carbon Metabolism: Clinical Implications in Endocrine Disorders.Neuroendocrinology · 2025Review
- Ischemic stroke in young Asians caused by spontaneous cervical artery dissection may be due to slightly increased homocysteine.Frontiers in neurology · 2025Article
- Parkinson's Disease Risk and Hyperhomocysteinemia: The Possible Link.Cellular and molecular neurobiology · 2023Review
- Evaluation of early retinal vascular changes by optical coherence tomography angiography in children with type 1 diabetes mellitus without diabetic retinopathy.International ophthalmology · 2022Article
- Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension.PPAR research · 2022Article
- The Effect of Homocysteine on the Secretion of Il-1β, Il-6, Il-10, Il-12 and RANTES by Peripheral Blood Mononuclear Cells-An In Vitro Study.Molecules (Basel, Switzerland) · 2021Article
- Role of PCSK9 in Homocysteine-Accelerated Lipid Accumulation in Macrophages and Atherosclerosis in ApoEFrontiers in cardiovascular medicine · 2021Article
- COVID-19's toll on the elderly and those with diabetes mellitus - Is vitamin B12 deficiency an accomplice?Medical hypotheses · 2021Review
- Article
- A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors.Journal of hematology & oncology · 2017Article
- Folate, homocysteine and the ovarian cycle among healthy regularly menstruating women.Human reproduction (Oxford, England) · 2017Article
- Interactions of hyperhomocysteinemia and T cell immunity in causation of hypertension.Canadian journal of physiology and pharmacology · 2017Review
- Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking.Frontiers in physiology · 2017Article
- Hyperhomocysteinemia Exacerbates Cisplatin-induced Acute Kidney Injury.International journal of biological sciences · 2017Article
- High levels of homocysteine downregulate apolipoprotein E expression via nuclear factor kappa B.World journal of biological chemistry · 2016Article
- Analysis for Carom complex, signaling and function by database mining.Frontiers in bioscience (Landmark edition) · 2016Article
- Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter.International journal of molecular sciences · 2015Article
- Association of homocysteine with type 1 diabetes mellitus: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease. Here, we studied transcriptional regulation in homocysteine (Hcy)-induced gene expression in monocytes (MC). We identified 11 Hcy-induced genes, 17 anti-inflammatory cytokine interleukin 10-induced, 8 pro-inflammatory cytokine interferon gamma (IFN gamma)-induced and 8 pro-inflammatory cytokine tumor necrosis factor alpha (TNF alpha)-induced genes through literature search. Binding frequency of 36 transcription factors (TFs) implicated in inflammation and MC differentiation were analyzed within core promoter regions of identified genes, and classified into 3 classes based on the significant binding frequency to the promoter of Hcy-induced genes. Class 1 TFs exert high significant binding frequency in Hcy-induced genes. Class 2 and 3 TFs have low and no significant binding frequency, respectively. Class 1 TF binding occurrence in Hcy-induced genes is similar to that in IFN gamma -induced genes, but not that in TNF alpha -induced. We conclude that Hcy is a pro-inflammatory amino acid and induces inflammatory transcriptional signal pathways mediated by class 1 TF. We term class 1 TF as putative Hcy-responsive TFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.