ArticleAIDS (London, England)2013
HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes.
Article in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- Cross-Reactive CD8 T-Cell Responses Elicited by Adenovirus Type 5-Based HIV-1 Vaccines Contributed to Early Viral Evolution in Vaccine Recipients Who Became Infected.Journal of virology · 2020Trial
- TEpiNom: A computational framework integrating population data to prioritize Plasmodium falciparum T cell epitopes.Vaccine · 2026Article
- Computational Prioritization of T Cell Epitopes to Overcome HLA Restriction and Antigenic Diversity inbioRxiv : the preprint server for biology · 2025Article
- Selective Diversity in RNA Viruses: Do They Know How to Evolve? A Hypothesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19.Nature communications · 2023Article
- Cytotoxic CD4Frontiers in immunology · 2023Review
- Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains.PLoS pathogens · 2022Article
- Functional Profile of CD8Frontiers in immunology · 2022Article
- Evolutionary Genetics ofMicroorganisms · 2021Review
- Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8Frontiers in immunology · 2021Article
- HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation.Molecular biology and evolution · 2020Article
- Immune escape and immune camouflage may reduce the efficacy of RTS,S vaccine in Malawi.Human vaccines & immunotherapeutics · 2020Article
- Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain TFrontiers in immunology · 2020Review
- Antigen processing and presentation in HIV infection.Molecular immunology · 2019Review
- CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection.PLoS pathogens · 2019Article
- Structural topology defines protective CD8Science (New York, N.Y.) · 2019Article
- Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating inFrontiers in immunology · 2019Article
- Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico.Journal of virology · 2018Article
- Interaction of the Host and Viral Genome and Their Influence on HIV Disease.Frontiers in genetics · 2018Review
- APOBEC3G Regulation of the Evolutionary Race Between Adaptive Immunity and Viral Immune Escape Is Deeply Imprinted in the HIV Genome.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo define the relative frequencies of different mechanisms of viral escape.
designA population-based approach to examine the distribution of HIV polymorphism associated with diverse population human leucocyte antigens (HLAs) at sites within and flanking CD8 T-cell epitopes as a correlate of likely mechanisms of viral escape.
methodsSequence windows surrounding 874 HLA allele-specific polymorphisms across the full HIV-1 proteomic consensus sequence were scanned by an epitope-prediction programme. Either already known or probable CD8 T-cell epitopes with HLA restriction matching that of the proximal HLA association were identified and synthesized. These peptides were used as stimulating antigens in automated enzyme-linked immunospot (ELISpot) assays. Peptide arrays were customized to each individual based on their HLA genotype.
resultsAmong HLA-associated HIV polymorphisms detected in the viral sequences of a cohort of 800 individuals with chronic subtype B HIV infection, those which were likely to affect HLA peptide binding were significantly more common than polymorphisms at nonanchor HLA binding sites. HIV epitopes with such polymorphisms were associated with reduced IFNγ responses in ELISpot assays. HIV escape at sites affecting T-cell receptor (TCR) engagement and epitope processing were also evident.
conclusionHIV escape from HLA-peptide binding predominates as an effective viral evasion strategy and therefore has implications for inclusion of HLA-adapted epitopes in vaccine immunogens.
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Registered trials
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