ArticleDiagnostic pathology2012
The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Review
- Association of TRPS1 gene with different EMT markers in ERα-positive and ERα-negative breast cancer.Diagnostic pathology · 2014Article
- Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.Diagnostic pathology · 2014Article
- Significance of ERβ expression in different molecular subtypes of breast cancer.Diagnostic pathology · 2014Article
- Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.Diagnostic pathology · 2013Article
- Clinico- pathological profile of patients with breast diseases.Diagnostic pathology · 2013Article
- Small breast epithelial mucin tumor tissue expression is associated with increased risk of recurrence and death in triple-negative breast cancer patients.Diagnostic pathology · 2013Article
- Long-term analysis to objectify the tumour grading by means of automated microscopic image analysis of the nucleolar organizer regions (AgNORs) in the case of breast carcinoma.Diagnostic pathology · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study is to explore the histopathological features and the molecular marker expression of young women with breast cancers.
methodsThe pathological data of 367 cases of female breast cancer patients were retrospectively analyzed, focusing on the analysis of young breast cancer incidence trends and the clinical and pathological features.
resultsCompared with elderly breast cancer patients, young women with breast cancers had larger tumor sizes, higher histological grades, and lymph node metastasis rates. The majority of patients were in the PTNM III stage, with the clinical and pathological features of strong invasiveness. The positive expression rate of the BRCA1 protein in the young group was higher than that in the old group. BRCA1 expression was positively correlated with the PTNM stage and axillary lymph node metastasis (P < 0.05).
conclusionsThe ectopic expression of BRCA1 is associated with the genesis, progression, and prognosis of young breast cancer patients. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1628000054838044.
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