ArticleInternational journal of ophthalmology2012
Retinoic acid metabolic change in retina and choroid of the guinea pig with lens-induced myopia.
Article in International journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid.Investigative ophthalmology & visual science · 2026Article
- AllJournal of the Royal Society, Interface · 2025Article
- Modulation of All-Trans Retinoic Acid by Light and Dopamine in the Murine Eye.Investigative ophthalmology & visual science · 2025Article
- Time-Serial Evaluation of the Development and Treatment of Myopia in Mice Eyes Using OCT and ZEMAX.Diagnostics (Basel, Switzerland) · 2023Article
- Effects of exogenous retinoic acid on ocular parameters in Guinea pigs with form deprivation myopia.Frontiers in cell and developmental biology · 2023Article
- Screening for novel risk factors related to high myopia using machine learning.BMC ophthalmology · 2022Article
- Candidate pathways for retina to scleral signaling in refractive eye growth.Experimental eye research · 2022Review
- Electroacupuncture Improves Choroidal Blood Flow to Inhibit the Development of Lens-Induced Myopia in Guinea Pigs.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- RNA-sequencing analysis reveals the long noncoding RNA profile in the mouse myopic retina.Frontiers in genetics · 2022Article
- Short Wavelength (Blue) Light Is Protective for Lens-Induced Myopia in Guinea Pigs Potentially Through a Retinoic Acid-Related Mechanism.Investigative ophthalmology & visual science · 2021Article
- IMI - Report on Experimental Models of Emmetropization and Myopia.Investigative ophthalmology & visual science · 2019Review
- Effect of Altered Retinal Cones/Opsins on Refractive Development under Monochromatic Lights in Guinea Pigs.Journal of ophthalmology · 2018Article
- Exploration and detection of potential regulatory variants in refractive error GWAS.Scientific reports · 2016Article
- Citicoline retards myopia progression following form deprivation in guinea pigs.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Oxidative Stress Levels in Aqueous Humor from High Myopic Patients.Korean journal of ophthalmology : KJO · 2016Article
- Article
- Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye.PloS one · 2015Article
- Light and myopia: from epidemiological studies to neurobiological mechanisms.Therapeutic advances in ophthalmologyReview
- All-trans-retinoic acid generation is an antidotal clearance pathway for all-trans-retinal in the retina.Journal of Zhejiang University. Science. BArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of retinoic acid (RA) and retinaldehyde dehydrogenase-2 (RALDH(2)) of retina and choroid in the guinea pig lens-induced myopic eyes.
methodsTotally 45 guinea pigs, at age of three weeks, were randomly assigned into three groups: the normal control, the lens-induced group and the recovering group. Out of focus was induced by the -6.00D concave lens on the left eye, and lasted for 15 days. All animals underwent biometric measurement (corneal radius of curvature, refraction and axial length). Subsequently, RA content in the retina and RPE/choriod complex was detected by reversed-phase high-performance liquid chromatography. RALDH(2) protein in the retina and RPE/choriod complex was evaluated by the immunohistochemical staining and Western blotting.
resultsAfter wearing -6.00D lens for 15 days, axial length of the lens-induced eye extends and myopia was formed, with RA contents increasing in both the neural retina and RPE/choroid complex. Comparing with the lens-induced group, myopic degree significantly relieved, and its RA contents in both the neural retina and RPE/choroid complex decreased in the recovering group. In the normal control, RALDH(2) protein was expressed positively in the retinal nerve fiber layer (RNFL), inner plexiform layer (IPL) and lateral border of outer nuclear layer (ONL). Retinal RALDH(2) protein increased in the lens-induced group, and was also positive in the outer plexiform layer (OPL). In the recovering group, retinal RALDH(2) protein attenuated the expression in the OPL turns to negative. RALDH(2) protein was not expressed in the choroid of any group.
conclusionRA of retina and chorid participates in the regulation of the lens-induced myopia in guinea pigs, which may be related with retinal RALDH(2) protein.
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