ArticleG3 (Bethesda, Md.)2012
Interactions of NADP-reducing enzymes across varying environmental conditions: a model of biological complexity.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Significance of Malic Enzyme 1 in Cancer: A Review.Current issues in molecular biology · 2025Review
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- Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background.Genetics · 2023Article
- Construction of a fatty acid metabolism-related gene signature for predicting prognosis and immune response in breast cancer.Frontiers in genetics · 2023Article
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- Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism.Journal of molecular endocrinology · 2020Review
- The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster.BMC genomics · 2020Article
- High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes.Molecular biology reports · 2020Article
- Tetrahydrobiopterin Plays a Functionally Significant Role in Lipogenesis in the Oleaginous FungusFrontiers in microbiology · 2020Article
- Effects of Methanol on Carotenoids as Well as Biomass and Fatty Acid Biosynthesis inApplied and environmental microbiology · 2019Article
- Article
- Carbohydrate Metabolic Compensation Coupled to High Tolerance to Oxidative Stress in Ticks.Scientific reports · 2019Article
- Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging.Nutrients · 2019Review
- Redox state affects fecundity and insecticide susceptibility in Anopheles gambiae.Scientific reports · 2018Article
- Transcriptome and gene expression analysis of docosahexaenoic acid producerBiotechnology for biofuels · 2018Article
- Sex and Genetic Background Influence Superoxide Dismutase (cSOD)-Related Phenotypic Variation inG3 (Bethesda, Md.) · 2017Article
- The impact of metagenomic interplay on the mosquito redox homeostasis.Free radical biology & medicine · 2017Review
- Defining Brugia malayi and Wolbachia symbiosis by stage-specific dual RNA-seq.PLoS neglected tropical diseases · 2017Article
- Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi.Scientific reports · 2015Article
- Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway.PLoS genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions across biological networks are often quantified under a single set of conditions; however, cellular behaviors are dynamic and interactions can be expected to change in response to molecular context and environment. To determine the consistency of network interactions, we examined the enzyme network responsible for the reduction of nicotinamide adenine dinucleotide phosphate (NADP) to NADPH across three different conditions: oxidative stress, starvation, and desiccation. Synthetic, activity-variant alleles were used in Drosophila melanogaster for glucose-6-phosphate dehydrogenase (G6pd), cytosolic isocitrate dehydrogenase (Idh), and cytosolic malic enzyme (Men) along with seven different genetic backgrounds to lend biological relevance to the data. The responses of the NADP-reducing enzymes and two downstream phenotypes (lipid and glycogen concentration) were compared between the control and stress conditions. In general, responses in NADP-reducing enzymes were greater under conditions of oxidative stress, likely due to an increased demand for NADPH. Interactions between the enzymes were altered by environmental stress in directions and magnitudes that are consistent with differential contributions of the different enzymes to the NADPH pool: the contributions of G6PD and IDH seem to be accentuated by oxidative stress, and MEN by starvation. Overall, we find that biological network interactions are strongly influenced by environmental conditions, underscoring the importance of examining networks as dynamic entities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.