ArticleG3 (Bethesda, Md.)2012
Differentiation-driven nucleolar association of the mouse imprinted Kcnq1 locus.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- iSMOD: an integrative browser for image-based single-cell multi-omics data.Nucleic acids research · 2023Article
- Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021Review
- Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization.Stem cell reports · 2020Review
- Long noncoding RNA functionality in imprinted domain regulation.PLoS genetics · 2020Review
- Article
- MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway.Journal of orthopaedic surgery and research · 2020Article
- Ribosomal DNA and the Nucleolus as Keystones of Nuclear Architecture, Organization, and Function.Trends in genetics : TIG · 2019Review
- Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin.Genome research · 2019Article
- Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.Nature communications · 2018Article
- Ki-67: more than a proliferation marker.Chromosoma · 2018Review
- Article
- Knockdown of Long Non-Coding RNA KCNQ1OT1 Restrained Glioma Cells' Malignancy by Activating miR-370/CCNE2 Axis.Frontiers in cellular neuroscience · 2017Article
- Dosage compensation of the sex chromosomes and autosomes.Seminars in cell & developmental biology · 2016Review
- Grabbing the genome by the NADs.Chromosoma · 2016Review
- Nucleolar DNA: the host and the guests.Histochemistry and cell biology · 2016Review
- The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation.Genome biology · 2015Article
- A survey of imprinted gene expression in mouse trophoblast stem cells.G3 (Bethesda, Md.) · 2015Article
- Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.Nucleic acids research · 2015Article
- Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development.Genes & development · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The organization of the genome within the mammalian nucleus is nonrandom, with physiologic processes often concentrated in specific three-dimensional domains. This organization may be functionally related to gene regulation and, as such, may play a role in normal development and human disease processes. However, the mechanisms that participate in nuclear organization are poorly understood. Here, we present data characterizing localization of the imprinted Kcnq1 alleles. We show that nucleolar association of the paternal allele (1) is stimulated during the differentiation of trophoblast stem cells, (ii) is dependent upon the Kcnq1ot1 noncoding RNA, (3) does not require polycomb repressive complex 2, and (4) is not sufficient to preclude transcription of imprinted genes. Although nucleolar positioning has been proposed as a mechanism to related to gene silencing, we find that silencing and perinucleolar localization through the Kcnq1ot1 noncoding RNA are separable events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.