Trial reportAJNR. American journal of neuroradiology
Recovery of white matter tracts in regions of peritumoral FLAIR hyperintensity with use of restriction spectrum imaging.
Trial report in AJNR. American journal of neuroradiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Structural and functional anatomy of the superior longitudinal fasciculus: a historical and contemporary narrative review.Anatomical science international · 2026Review
- The role of diffusion-weighted MRI in biological image-guided radiation therapy: a roadmap.Physics in medicine and biology · 2026Review
- Understanding tractography in edematous brain regions: challenges and solutions.Brain structure & function · 2025Review
- A review on surgical treatment options in gliomas.Frontiers in oncology · 2023Review
- Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain.Nature communications · 2022Article
- Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates.Frontiers in neurology · 2022Review
- Effects of Multi-Shell Free Water Correction on Glioma Characterization.Diagnostics (Basel, Switzerland) · 2021Article
- Association of Outdoor Ambient Fine Particulate Matter With Intracellular White Matter Microstructural Properties Among Children.JAMA network open · 2021Article
- Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas.Neurosurgery · 2021Article
- Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma.Frontiers in immunology · 2021Review
- Associations between age and brain microstructure in older community-dwelling men and women: the Rancho Bernardo Study.Neurobiology of aging · 2020Article
- Surgical oncology for gliomas: the state of the art.Nature reviews. Clinical oncology · 2018Review
- Decreased neurite density within frontostriatal networks is associated with executive dysfunction in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2018Article
- Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI.Journal of magnetic resonance imaging : JMRI · 2017Review
- Simultaneous assessment of cerebral blood volume and diffusion heterogeneity using hybrid IVIM and DK MR imaging: initial experience with brain tumors.European radiology · 2017Article
- Performance of unscented Kalman filter tractography in edema: Analysis of the two-tensor model.NeuroImage. Clinical · 2017Article
- Restriction spectrum imaging reveals decreased neurite density in patients with temporal lobe epilepsy.Epilepsia · 2016Article
- Future directions of operative neuro-oncology.Journal of neuro-oncology · 2016Review
- Restriction spectrum imaging predicts response to bevacizumab in patients with high-grade glioma.Neuro-oncology · 2016Article
- Corticospinal tract modeling for neurosurgical planning by tracking through regions of peritumoral edema and crossing fibers using two-tensor unscented Kalman filter tractography.International journal of computer assisted radiology and surgery · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeDTI is being increasingly used to visualize critical white matter tracts adjacent to brain tumors before neurosurgical resection. However, brain tumors, particularly high-grade gliomas, are typically surrounded by regions of FLAIR hyperintensity that include edema, which increase isotropic diffusion, degrading the ability of standard DTI to uncover orientation estimates within these regions. We introduce a new technique, RSI, which overcomes this limitation by removing the spherical, fast diffusion component introduced by edema, providing better analysis of white matter architecture. MATERIALS AND
methodsA total of 10 patients with high-grade gliomas surrounded by FLAIR-HI that at least partially resolved on follow-up imaging were included. All patients underwent RSI and DTI at baseline (FLAIR-HI present) and at follow-up (FLAIR-HI partially resolved). FA values obtained with RSI and DTI were compared within regions of FLAIR-HI and NAWM at both time points.
resultsRSI showed higher FA in regions of FLAIR-HI and NAWM relative to DTI, reflecting the ability of RSI to specifically measure the slow, restricted volume fraction in regions of edema and NAWM. Furthermore, a method by time interaction revealed that FA estimates increased when the FLAIR-HI resolved by use of standard DTI but remained stable with RSI. Tractography performed within the region of FLAIR-HI revealed the superior ability of RSI to track fibers through severe edema relative to standard DTI.
conclusionsRSI improves the quantification and visualization of white matter tracts in regions of peritumoral FLAIR-HI associated with edema relative to standard DTI and may provide a valuable tool for neurosurgical planning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.