ArticleNucleic acids research2013
A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2,2'-diethyl-9-methyl-selenacarbocyanine bromide.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Transport Properties of Self-Assembling G-Hydrogels: Evidence for a Tunable Fickian Diffusivity.The journal of physical chemistry. B · 2025Article
- Structure, Topology, and Stability of Multiple G-quadruplexes in Long Telomeric Overhangs.Journal of molecular biology · 2024Review
- Engineering DNA quadruplexes in DNA nanostructures for biosensor construction.Nano research · 2022Review
- A DNA small molecular probe with increasing KRSC advances · 2021Article
- Disassembly of Dimeric Cyanine Dye Supramolecular Assembly by Tetramolecular G-quadruplex Dependence on Linker Length and Layers of G-quartet.Molecules (Basel, Switzerland) · 2019Article
- Spontaneous formation and reversible transformation between achiral J- and chiral H-aggregates of cyanine dye MTC.RSC advances · 2019Article
- In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?Journal of nucleic acids · 2017Review
- Structure, Properties, and Biological Relevance of the DNA and RNA G-Quadruplexes: Overview 50 Years after Their Discovery.Biochemistry. Biokhimiia · 2016Article
- Directly lighting up RNA G-quadruplexes from test tubes to living human cells.Nucleic acids research · 2015Article
- G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy.Chemical science · 2015Article
- Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes.Nucleic acids research · 2014Article
- Mechanistic insight into ligand binding to G-quadruplex DNA.Nucleic acids research · 2014Article
- Discovery of a structural-element specific G-quadruplex "light-up" probe.Scientific reports · 2014Article
- Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores.RSC advances · 2014Article
- Photonic DNA-chromophore nanowire networks: harnessing multiple supramolecular assembly modes.Langmuir : the ACS journal of surfaces and colloids · 2013Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
G-quadruplexes have attracted growing attention as a potential cancer-associated target for both treatment and detection in recent years. For detection purpose, high specificity is one of the most important factors to be considered in G-quadruplex probe design. It is well known that end stacking and groove binding are two dominated quadruplex-ligand binding modes, and currently most reported G-quadruplex probes are designed based on the former, which has been proven to show good selectivity between quadruplexes and non-quadruplexes. Because groove of G-quadruplex also has some unique chemical properties, it could be inferred that probes that can interact with both the groove and G-tetrad site of certain G-quadruplexes simultaneously might possess higher specificity in aspects of discriminating different quadruplexes. In this article, we report a cyanine dye as a potential novel probe scaffold that could occupy both the 5'-end external G-tetrad and the corresponding groove of the G-quadruplex simultaneously. By using various spectrum and nuclear magnetic resonance techniques, we give a detailed binding characterization for this dual-site simultaneous binding mode. A preliminary result suggests that this mode might provide highly specific recognition to a parallel-stranded G-quadruplex. These findings and the structural elucidation might give some clues in aspects of developing highly specific G-quadruplex probes.
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