ArticleApplied and environmental microbiology2013
Biomass conversion inhibitors furfural and 5-hydroxymethylfurfural induce formation of messenger RNP granules and attenuate translation activity in Saccharomyces cerevisiae.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
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- Fungistatic effect of sorbic acid on yeast cells via translational repression involving eIF2Microbial cell (Graz, Austria) · 2026Article
- The Impact of Production Technology on the Quality of Potato Spirit.Molecules (Basel, Switzerland) · 2025Article
- Simultaneous Determination of Yeast Inhibitors 5‑HMF and Furfural in Hydrolyzed Lignocellulosic Biomass using HPLC-PDA.ACS omega · 2025Article
- Perspectives on current and future yeast technologies for ethanol-based biofuels and bioproducts.FEMS yeast research · 2025Review
- Toxicants improve glycerol production in the fermentation of undetoxified hydrolysate by Candida glycerinogenes.Biotechnology letters · 2024Article
- Recent Advances in Food Waste Transformations into Essential Bioplastic Materials.Molecules (Basel, Switzerland) · 2024Review
- Contribution of the yeast bi-chaperone system in the restoration of the RNA helicase Ded1 and translational activity under severe ethanol stress.The Journal of biological chemistry · 2023Article
- Yarrowia lipolytica produces lipid-rich biomass in medium mimicking lignocellulosic biomass hydrolysate.Applied microbiology and biotechnology · 2023Article
- Structural and Biochemical Analysis of the Furan Aldehyde Reductase YugJ fromInternational journal of molecular sciences · 2022Article
- Proteomic analysis revealed the roles of YRR1 deletion in enhancing the vanillin resistance of Saccharomyces cerevisiae.Microbial cell factories · 2021Article
- Targeting stress granules: A novel therapeutic strategy for human diseases.Pharmacological research · 2020Review
- Characterizing an engineered carotenoid-producing yeast as an anti-stress chassis for building cell factories.Microbial cell factories · 2019Article
- Bioethanol production from sugarcane leaf waste: Effect of various optimized pretreatments and fermentation conditions on process kinetics.Biotechnology reports (Amsterdam, Netherlands) · 2019Article
- The Role ofMolecules (Basel, Switzerland) · 2019Article
- Evaluation of divergent yeast genera for fermentation-associated stresses and identification of a robust sugarcane distillery waste isolateBiotechnology for biofuels · 2019Article
- Chemical Pretreatment-Independent Saccharifications of Xylan and Cellulose of Rice Straw by Bacterial Weak Lignin-Binding Xylanolytic and Cellulolytic Enzymes.Applied and environmental microbiology · 2017Article
- Acetic Acid Causes Endoplasmic Reticulum Stress and Induces the Unfolded Protein Response inFrontiers in microbiology · 2017Article
- The Absence of the Transcription Factor Yrr1p, Identified from Comparative Genome Profiling, Increased Vanillin Tolerance Due to Enhancements of ABC Transporters Expressing, rRNA Processing and Ribosome Biogenesis inFrontiers in microbiology · 2017Article
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4 authors at 1 institution in 1 country.
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Abstract
Various forms of stress can cause an attenuation of bulk translation activity and the accumulation of nontranslating mRNAs into cytoplasmic messenger RNP (mRNP) granules termed processing bodies (P-bodies) and stress granules (SGs) in eukaryotic cells. Furfural and 5-hydroxymethylfurfural (HMF), derived from lignocellulosic biomass, inhibit yeast growth and fermentation as stressors. Since there is no report regarding their effects on the formation of cytoplasmic mRNP granules, here we investigated whether furfural and HMF cause the assembly of yeast P-bodies and SGs accompanied by translational repression. We found that furfural and HMF cause the attenuation of bulk translation activity and the assembly of cytoplasmic mRNP granules in Saccharomyces cerevisiae. Notably, a combination of furfural and HMF induced the remarkable repression of translation initiation and SG formation. These findings provide new information about the physiological effects of furfural and HMF on yeast cells, and also suggest the potential usefulness of cytoplasmic mRNP granules as a warning sign or index of the deterioration of cellular physiological status in the fermentation of lignocellulosic hydrolysates.
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