ArticleDiabetes care2013
Glucose-independent ethnic differences in HbA1c in people without known diabetes.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Characteristics of participants who take up screening tests for diabetes and lipid disorders: a systematic review.BMJ open · 2022Pooled it
- Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Guideline
- Associations between estimated glucose disposal rate and peripheral artery disease: evidence from the UK Biobank and NHANES.Nutrition & metabolism · 2026Article
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Improving Diabetes and Pre-Diabetes Detection in the UK: Insights From HbA1c Screening in an Acute Hospital's Emergency Department.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Prediabetes and Cardiometabolic Risk: The Need for Improved Diagnostic Strategies and Treatment to Prevent Diabetes and Cardiovascular Disease.Biomedicines · 2024Review
- Ethnicity, Age, and Gender Differences in Glycated Hemoglobin (HbA1c) Levels among Adults in Northern and Eastern Sudan: A Community-Based Cross-Sectional Study.Life (Basel, Switzerland) · 2023Article
- Early postpartum HbA1c after hyperglycemia first detected in pregnancy-Imperfect but not without value.PloS one · 2023Article
- Association of glycated hemoglobin ACardiovascular diabetology · 2021Article
- Elevated Serum TNF-Journal of obesity · 2020Article
- Article
- Diabetes case finding in the emergency department, using HbA1c: an opportunity to improve diabetes detection, prevention, and care.BMJ open diabetes research & care · 2016Article
- Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331,288 participants.The lancet. Diabetes & endocrinology · 2015Article
- Observational
- Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation.American journal of hematology · 2015Article
- Monitoring HIV-infected Patients with Diabetes: Hemoglobin A1c, Fructosamine, or Glucose?Clinical medicine insights. Endocrinology and diabetes · 2014Article
- Development of a new risk score for incident type 2 diabetes using updated diagnostic criteria in middle-aged and older chinese.PloS one · 2014Article
- Comment on: Selvin et al. No racial differences in the association of glycated hemoglobin with kidney disease and cardiovascular outcomes. Diabetes Care 2013;36:2995-3001.Diabetes care · 2013Article
- Led Astray by Hemoglobin A1c: A Case of Misdiagnosis of Diabetes by Falsely Elevated Hemoglobin A1c.Journal of investigative medicine high impact case reportsArticle
- Commentary: Diagnostic Validity and Clinical Utility of HbA1c Tests for Type 2 Diabetes Mellitus.Current diabetes reviewsArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether glucose-independent differences in HbA1c exist between people of African, South Asian, and Chinese ethnicities. RESEARCH DESIGN AND
methodsData from 6,701 people aged 19-78 years, without known diabetes, from Mauritius, and participating in the population-based Non-Communicable Disease Surveys of the main island and the island of Rodrigues were included. Participants were African (n = 1,219 from main island, n = 1,505 from Rodrigues), South Asian (n = 3,820), and Chinese (n = 157). Survey data included HbA1c, plasma glucose during oral glucose tolerance testing (OGTT), anthropometry, demographics, and medical and lifestyle history.
resultsMean HbA1c, after adjustment for fasting and 2-h plasma glucose and other factors known to influence HbA1c, was higher in Africans from Rodrigues (6.1%) than in South Asians (5.7%, P < 0.001), Chinese (5.7%, P < 0.001), or Africans from the main island of Mauritius (5.7%, P < 0.001). The age-standardized prevalence of diabetes among Africans from Rodrigues differed substantially depending on the diagnostic criteria used [OGTT 7.9% (95% CI 5.8-10.0); HbA1c 17.3% (15.3-19.2)]. Changing diagnostic criteria resulted in no significant change in the prevalence of diabetes within the other ethnic groups.
conclusionsPeople of African ethnicity from Rodrigues have higher HbA1c than those of South Asian or African ethnicity from the main island of Mauritius for reasons not explained by plasma glucose during an OGTT or traditional factors known to affect glycemia. Further research should be directed at determining the mechanism behind this disparity and its relevance to clinical outcomes.
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