Evidence map›Paper›PMID 23275201›Full record

ArticleMolecular biology reports2013

Modulation of hsa-miR-26b levels following adipokine stimulation.

Guangfeng Xu, Chenbo Ji, Chunmei Shi, Hailong Fu, Lingling Zhu, Lu Zhu, Lulian Xu, Ling Chen, Yueying Feng, Yaping Zhao and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

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  7. MiR-26b-5p regulates the preadipocyte differentiation by targeting FGF21 in goats.In vitro cellular & developmental biology. Animal · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Guangfeng XuDepartment of Laboratory Medicine, The 82nd Hospital of the People's Liberation Army, No.100 Jiankang East Road, Huaian 223001, China.
Chenbo Ji
Chunmei Shi
Hailong Fu
Lingling Zhu
Lu Zhu
Lulian Xu
Ling Chen
Yueying Feng
Yaping Zhao
Xirong Guo
Nanjing Medical University · CNNanjing Maternity and Child Health Care Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that are involved in post-transcriptional regulation of gene expression. Hsa-miR-26b is an intronic miRNA located in the intron of CTDSP1 (carboxy-terminal domain, RNA polymerase II, polypeptide A, small phosphatase 1). In the present study, the expression of hsa-miR-26b was examined during human preadipocyte differentiation. 15 days after induction of differentiation, mature human adipocytes were treated with adipokines. Hsa-miR-26b was differentially expressed during human preadipocyte differentiation. Tumor necrosis factor-α (TNF-α), leptin and resistin, but not interleukin-6, caused downregulation of hsa-miR-26b expression in adipocytes. These results suggest that the expression of hsa-miR-26b is affected by TNF-α, leptin and resistin and that hsa-miR-26b may be an important mediator in regulating the obesity-related insulin sensitivity and inflammatory responses.

Indexed as

AdipocytesAdipokinesCells, CulturedGene Expression RegulationHumansInterleukin-6LeptinMicroRNAsObesityResistinTumor Necrosis Factor-alphaAdipokinesInterleukin-6LeptinMicroRNAsMIRN26 microRNA, humanResistinTumor Necrosis Factor-alpha

Identifiers

PMID23275201
OpenAlexW2067521961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.