ArticleThe journal of physiological sciences : JPS2013
Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus.
Article in The journal of physiological sciences : JPS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice.Nature communications · 2026Article
- Article
- Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation.International journal of molecular sciences · 2023Review
- Spatiotemporal Control of Noradrenaline-Dependent Synaptic Transmission in Mouse Dorsal Raphe Serotonin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Potassium Channel Conductance Is Involved in Phenylephrine-Induced Spontaneous Firing of Serotonergic Neurons in the Dorsal Raphe Nucleus.Frontiers in cellular neuroscience · 2022Article
- Gray areas: Neuropeptide circuits linking the Edinger-Westphal and Dorsal Raphe nuclei in addiction.Neuropharmacology · 2021Review
- Current Limitations and Candidate Potential of 5-HT7 Receptor Antagonism in Psychiatric Pharmacotherapy.Frontiers in psychiatry · 2021Review
- Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions.International journal of molecular sciences · 2020Review
- Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus.Biomolecules · 2020Article
- Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HTInternational journal of molecular sciences · 2019Article
- Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions.Biomolecules · 2019Article
- Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Additive effect of 5-HT2C and CB1 receptor blockade on the regulation of sleep-wake cycle.BMC neuroscience · 2019Article
- The 5-HTPsychopharmacology · 2018Article
- Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.Molecular psychiatry · 2018Article
- Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.Science advances · 2017Article
- Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.Physiological reports · 2017Article
- Selective Modulation of KFrontiers in cellular neuroscience · 2017Article
- Neuroanatomical Substrates of Rodent Social Behavior: The Medial Prefrontal Cortex and Its Projection Patterns.Frontiers in neural circuits · 2017Review
- Afferent Inputs to Neurotransmitter-Defined Cell Types in the Ventral Tegmental Area.Cell reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsal raphe nucleus (DRN) is the origin of the central serotonin [5-hydroxytryptamine (5-HT)] system and plays an important role in the regulation of many physiological functions such as sleep/arousal, food intake and mood. In order to understand the regulatory mechanisms of 5-HT system, characterization of the types of neurons is necessary. We performed electrophysiological recordings in acute slices of glutamate decarboxylase 67-green fluorescent protein knock-in mice. We utilized this mouse to identify visually GABAergic cells. Especially, we examined postsynaptic responses mediated by 5-HT receptors between GABAergic and serotonergic cells in the DRN. Various current responses were elicited by 5-HT and 5-HT(1A) or 5-HT(2A/2C) receptor agonists in GABAergic cells. These results suggested that multiple 5-HT receptor subtypes overlap on GABAergic cells, and their combination might control 5-HT cells. Understanding the postsynaptic 5-HT feedback mechanisms may help to elucidate the 5-HT neurotransmitter system and develop novel therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.