ArticleInfection and immunity2013
Sequencing and functional annotation of avian pathogenic Escherichia coli serogroup O78 strains reveal the evolution of E. coli lineages pathogenic for poultry via distinct mechanisms.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 93 citations in OpenAlex.
- Comparative Genomic Analysis of Multidrug-Resistant Escherichia coli Across Poultry-Human-Environmental Interfaces.MicrobiologyOpen · 2026Article
- Molecular epidemiology reveals distinct lineages and genomic profiles of avian pathogenic and commensalMicrobial genomics · 2026Article
- Prophage diversity in poultry-associatedFrontiers in microbiology · 2026Article
- Article
- Poultry pathogenicity, antimicrobial resistance, and one health genomic characterization of ST83 Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Comprehensive Genomic and Phenotypic Characterization ofMicroorganisms · 2025Article
- Serogroup Prevalence, Virulence Profile and Antibiotic Resistance of Avian PathogenicVeterinary sciences · 2025Article
- Serogrouping and Molecular Characterization of ESBL-Producing Avian PathogenicAntibiotics (Basel, Switzerland) · 2025Article
- Genes associated with fitness and disease severity in the pan-genome of mastitis-associatedFrontiers in microbiology · 2024Article
- Assessment of an Enterobactin Conjugate Vaccine in Layers to Protect Their Offspring from Colibacillosis.Pathogens (Basel, Switzerland) · 2023Article
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- Modification of avian pathogenic Escherichia coli χ7122 lipopolysaccharide increases accessibility to glycoconjugate antigens.Microbial cell factories · 2022Article
- A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E. coli.Cell reports · 2022Article
- Isolation, Molecular Characterization, and Antibiotic Resistance of Avian PathogenicVeterinary sciences · 2022Article
- Characteristics, pathogenic mechanism, zoonotic potential, drug resistance, and prevention of avian pathogenicFrontiers in microbiology · 2022Review
- Poultry gut health - microbiome functions, environmental impacts, microbiome engineering and advancements in characterization technologies.Journal of animal science and biotechnology · 2021Review
- Multivalent poultry vaccine development using Protein Glycan Coupling Technology.Microbial cell factories · 2021Article
- Surviving Serum: the Escherichia coliInfection and immunity · 2021Article
- Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family.Frontiers in molecular biosciences · 2021Review
- Acid-Sensing Histidine Kinase With a Redox Switch.Frontiers in microbiology · 2021Article
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Authors and funding
17 authors at 6 institutions in 3 countries.
Funding
Abstract
Avian pathogenic Escherichia coli (APEC) causes respiratory and systemic disease in poultry. Sequencing of a multilocus sequence type 95 (ST95) serogroup O1 strain previously indicated that APEC resembles E. coli causing extraintestinal human diseases. We sequenced the genomes of two strains of another dominant APEC lineage (ST23 serogroup O78 strains χ7122 and IMT2125) and compared them to each other and to the reannotated APEC O1 sequence. For comparison, we also sequenced a human enterotoxigenic E. coli (ETEC) strain of the same ST23 serogroup O78 lineage. Phylogenetic analysis indicated that the APEC O78 strains were more closely related to human ST23 ETEC than to APEC O1, indicating that separation of pathotypes on the basis of their extraintestinal or diarrheagenic nature is not supported by their phylogeny. The accessory genome of APEC ST23 strains exhibited limited conservation of APEC O1 genomic islands and a distinct repertoire of virulence-associated loci. In light of this diversity, we surveyed the phenotype of 2,185 signature-tagged transposon mutants of χ7122 following intra-air sac inoculation of turkeys. This procedure identified novel APEC ST23 genes that play strain- and tissue-specific roles during infection. For example, genes mediating group 4 capsule synthesis were required for the virulence of χ7122 and were conserved in IMT2125 but absent from APEC O1. Our data reveal the genetic diversity of E. coli strains adapted to cause the same avian disease and indicate that the core genome of the ST23 lineage serves as a chassis for the evolution of E. coli strains adapted to cause avian or human disease via acquisition of distinct virulence genes.
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