ArticleAge (Dordrecht, Netherlands)2013
In vitro tenocyte metabolism in aging and oestrogen deficiency.
Article in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tendinopathy: sex bias starts from the preclinical development of tendon treatments. A systematic review.Biology of sex differences · 2022Pooled it
- Genetic and familial predisposition to rotator cuff disease: a systematic review.Journal of shoulder and elbow surgery · 2017Pooled it
- Does menopausal hormone therapy (MHT), exercise or a combination of both, improve pain and function in post-menopausal women with greater trochanteric pain syndrome (GTPS)? A randomised controlled trial.BMC women's health · 2016Trial
- Serial sarcomere adaptation to eccentric overload training is blunted in ovariectomized rats.Physiological reports · 2026Article
- Sex Hormones & Exercise in the Musculoskeletal System: From Signaling to Structure and Function.Endocrine reviews · 2026Article
- Beyond local injury: pathogenic roles of metabolic, endocrine, and aging-associated systemic factors in tendinopathy and novel therapeutic strategies.Journal of orthopaedic surgery and research · 2026Review
- Comparative analysis of different macromolecular crowding agents in human tenocyte cultures.Biomaterials and biosystems · 2026Article
- Estrogen and Progesterone Exhibit Distinct Yet Coordinated Roles in the Regulation of Tendon Extracellular Matrix Remodeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Impact of aging and estrogen deficiency on extracellular matrix-related gene expression in rotator cuff tendons: in vitro and in vivo rat model.JSES international · 2025Article
- Estrogen and progesterone exhibit distinct yet coordinated roles in the regulation of tendon extracellular matrix remodeling.bioRxiv : the preprint server for biology · 2025Article
- Sex Differences and Extracorporeal Shockwave Therapy Outcomes in Runners with Achilles or Hamstring Tendinopathy.Journal of clinical medicine · 2024Article
- Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study.Calcified tissue international · 2024Article
- The tendon unit: biochemical, biomechanical, hormonal influences.Journal of orthopaedic surgery and research · 2023Review
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- Age-related changes in mechanical properties of semitendinosus tendon used for anterior cruciate ligament reconstruction.Journal of orthopaedic surgery and research · 2022Article
- Increasing Vascular Response to Injury Improves Tendon Early Healing Outcome in Aged Rats.Annals of biomedical engineering · 2022Article
- The role of estrogen and progesterone receptors in the rotator cuff disease: a retrospective cohort study.BMC musculoskeletal disorders · 2021Article
- The Impact of Genistein Supplementation on Tendon Functional Properties and Gene Expression in Estrogen-Deficient Rats.Journal of medicinal food · 2020Article
- Association of estrogen receptor β polymorphisms with posterior tibial tendon dysfunction.Molecular and cellular biochemistry · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about tendons and tenocyte biological behaviour during aging and, especially, oestrogen deficiency. The aim of this study was to evaluate in vitro the proliferation and metabolism of tenocytes isolated from the Achilles tendons of ovariectomised (OVX), middle-aged (OLD) and young (YOUNG) rats. An in vitro model of micro-wound healing was also used to assess age and oestrogen deficiency differences in tendon healing. In standard culture condition, OLD and OVX tenocytes showed a significantly lower proliferation rate, collagen I, aggrecan and elastin than YOUNG ones. In OVX group, fibronectin and elastin significantly decreased in comparison to YOUNG and OLD groups, respectively, whereas vascular endothelial growth factor and metalloproteinases-13 increased than those of both YOUNG and OLD groups. In the micro-wound healing model, tenocytes from both OVX and OLD showed a significantly lower healing rate, proliferation rate, collagen I and nitrix oxide in comparison to YOUNG. OVX elastin value was significantly lower than YOUNG one and OVX healing rate and cell migration speed, proliferation rate and fibronectin results were lower, whereas collagen III and metalloproteinase-13 higher in comparison to both YOUNG and OLD groups. These results highlighted how aging and, more significantly, oestrogen deficiency negatively affect tendon metabolism and healing. Our work improves the body of knowledge on the effects of senescence and oestrogen deficiency on tenocyte behaviour and allows further studies to find solution for the prevention of tendon injuries in aging and menopause.
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Registered trials
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