ArticleThe American journal of pathology1990
Sequential events in the pathogenesis of streptococcal cell wall-induced arthritis and their modulation by bis(5-amidino-2-benzimidazolyl)methane (BABIM).
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis.Journal of natural products · 2009Article
- Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis.Journal of natural products · 2006Article
- Anti-Pneumocystis activities of aromatic diamidoxime prodrugs.Antimicrobial agents and chemotherapy · 1998Article
- Selective plasma kallikrein inhibitor attenuates acute intestinal inflammation in Lewis rat.Digestive diseases and sciences · 1996Article
- Control of glucan-induced systemic granulomatosis by cyclosporine A.Inflammation · 1995Article
- Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition.Antimicrobial agents and chemotherapy · 1993Article
- Phlogistic properties of peptidoglycan-polysaccharide polymers from cell walls of pathogenic and normal-flora bacteria which colonize humans.Infection and immunity · 1993Review
- Suppression of local and systemic responses in streptococcal cell wall-induced acute inflammation of the air pouch by cyclosporine A. Comparison with the effects of two anti-inflammatory bis-benzimidazoles.The American journal of pathology · 1993Article
- Bone-resorbing activity is expressed by rat macrophages in response to arthropathic streptococcal cell wall polymers.Inflammation · 1992Article
- Streptococcal cell wall-induced systemic disease. Beneficial effects of trans-bis(5-amidino-2-benzimidazolyl)ethene, a novel, macrophage-directed anti-inflammatory agent.The American journal of pathology · 1991Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This report builds on the authors' earlier discovery of bis(5-amidino-2-benzimidazolyl)methane (BABIM) as a strong suppressive agent for streptococcal cell wall fragment-induced arthritis in the Lewis rat. As a synthetic inhibitor of trypsinlike proteases, BABIM opens up a new route to the control of inflammatory joint disease. To gain a deeper insight into the function of the compound, the authors have now studied its influence on the sequential development of the joint changes and the associated lesions in spleen and liver. Bis(5-amidino-2-benzimidazolyl)methane is shown to block acute synovitis, to retard and reduce granuloma formation in spleen and liver, to decrease neutrophilic leukocytosis, and to diminish hemopoietic hyperplasia in the bone, and thus also to mitigate the distinctive osteoclastic and chondroclastic events. The compound does not interfere with the splenic immune response, the temporary rise in hepatocytic mitotic activity, or the organ deposition of streptococcal cell walls.
Indexed as
Identifiers
2327474PMC1877637W253236530What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.