ReviewPsychopharmacology2013
The hidden side of drug action: brain temperature changes induced by neuroactive drugs.
Review in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Extreme ambient temperature and emergency healthcare service utilization due to substance use disorders: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Repeated saline injections reduce the pulmonary allergic inflammatory response in rats by inducing short-term stress.Brain, behavior, & immunity - health · 2024Article
- Acupuncture inhibition of methamphetamine-induced behaviors, dopamine release and hyperthermia in the nucleus accumbens: mediation of group II mGluR.Addiction biology · 2019Article
- Changes in brain oxygen and glucose induced by oxycodone: Relationships with brain temperature and peripheral vascular tone.Neuropharmacology · 2018Article
- Inflow of oxygen and glucose in brain tissue induced by intravenous norepinephrine: relationships with central metabolic and peripheral vascular responses.Journal of neurophysiology · 2018Article
- Cognitive Functioning in Schizophrenia, Methamphetamine-induced Psychotic Disorder, and Healthy People: A Comparative Study.Advanced biomedical research · 2018Article
- Brain temperature effects of intravenous heroin: State dependency, environmental modulation, and the effects of dose.Neuropharmacology · 2017Article
- Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application.Psychopharmacology · 2017Review
- Effects of social interaction and warm ambient temperature on brain hyperthermia induced by the designer drugs methylone and MDPV.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia.European journal of pharmacology · 2014Article
- Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure.Reviews in the neurosciences · 2014Review
- Mind the mortality gap: the importance of metabolic function in mental illnesses.Psychopharmacology · 2013Article
- Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders.Psychopharmacology · 2013Article
- Physiological fluctuations in brain temperature as a factor affecting electrochemical evaluations of extracellular glutamate and glucose in behavioral experiments.ACS chemical neuroscience · 2013Review
- Effects of MDMA on body temperature in humans.Temperature (Austin, Tex.)Article
- Saturday night fever in ecstasy/MDMA dance clubbers: Heightened body temperature and associated psychobiological changes.Temperature (Austin, Tex.)Article
- Brain temperature could affect neurochemical evaluations.Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
rationaleMost neuroactive drugs affect brain metabolism as well as systemic and cerebral blood flow, thus altering brain temperature. Although this aspect of drug action usually remains in the shadows, drug-induced alterations in brain temperature reflect their metabolic neural effects and affect neural activity and neural functions.
objectivesHere, I review brain temperature changes induced by neuroactive drugs, which are used therapeutically (general anesthetics), as a research tool (dopamine agonists and antagonists), and self-administered to induce desired psychic effects (cocaine, methamphetamine, ecstasy). I consider the mechanisms underlying these temperature fluctuations and their influence on neural, physiological, and behavioral effects of these drugs.
resultsBy interacting with neural mechanisms regulating metabolic activity and heat exchange between the brain and the rest of the body, neuroactive drugs either increase or decrease brain temperatures both within (35-39 °C) and exceeding the range of physiological fluctuations. These temperature effects differ drastically depending upon the environmental conditions and activity state during drug administration. This state-dependence is especially important for drugs of abuse that are usually taken by humans during psycho-physiological activation and in environments that prevent proper heat dissipation from the brain. Under these conditions, amphetamine-like stimulants induce pathological brain hyperthermia (>40 °C) associated with leakage of the blood-brain barrier and structural abnormalities of brain cells.
conclusionsThe knowledge on brain temperature fluctuations induced by neuroactive drugs provides new information to understand how they influence metabolic neural activity, why their effects depend upon the behavioral context of administration, and the mechanisms underlying adverse drug effects including neurotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.