ReviewProtoplasma2013
Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions.
Review in Protoplasma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- The vinculin-β-catenin axis promotes bone formation and repair: an essential prerequisite for the anti-osteoporotic efficacy of sclerostin-neutralizing antibody.Science China. Life sciences · 2026Article
- Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro.Nature communications · 2026Article
- Inhibition of neutrophil extracellular traps alleviates blood-brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy.Journal of neuroinflammation · 2025Article
- N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity.Nature communications · 2024Article
- Vinculin Y822 is an important determinant of ligand binding.Journal of cell science · 2023Article
- Loss-of-function or gain-of-function variations in VINCULIN (VCL) are risk factors of human neural tube defects.Molecular genetics & genomic medicine · 2021Article
- Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction.Scientific reports · 2019Article
- The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis.The Journal of cell biology · 2018Article
- Histamine causes endothelial barrier disruption via CaScientific reports · 2018Article
- Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions.Journal of cell science · 2018Article
- Stiff Substrates Increase Inflammation-Induced Endothelial Monolayer Tension and Permeability.Biophysical journal · 2017Article
- Selective Role of Vinculin in Contractile Mechanisms of Endothelial Permeability.American journal of respiratory cell and molecular biology · 2016Article
- Nanonet Force Microscopy for Measuring Cell Forces.Biophysical journal · 2016Article
- Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses.Cellular signalling · 2016Article
- Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.Science translational medicine · 2015Article
- Changes in integrin αv, vinculin and connexin43 in the medial prefrontal cortex in rats under single-prolonged stress.Molecular medicine reports · 2015Article
- From stem cells to cardiomyocytes: the role of forces in cardiac maturation, aging, and disease.Progress in molecular biology and translational science · 2014Review
- Contact inhibition of locomotion probabilities drive solitary versus collective cell migration.Journal of the Royal Society, Interface · 2013Article
- A mechanobiological perspective on cadherins and the actin-myosin cytoskeleton.F1000prime reports · 2013Review
- α-catenin, vinculin, and F-actin in strengthening E-cadherin cell-cell adhesions and mechanosensing.Cell adhesion & migrationArticle
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell adhesion junctions characteristically arise from the cooperative integration of adhesion receptors, cell signalling pathways and the cytoskeleton. This is exemplified by cell-cell interactions mediated by classical cadherin adhesion receptors. These junctions are sites where cadherin adhesion systems functionally couple to the dynamic actin cytoskeleton, a process that entails physical interactions with many actin regulators and regulation by cell signalling pathways. Such integration implies a potential role for molecules that may stand at the interface between adhesion, signalling and the cytoskeleton. One such candidate is the cortical scaffolding protein, vinculin, which is a component of both cell-cell and cell-matrix adhesions. While its contribution to integrin-based adhesions has been extensively studied, less is known about how vinculin contributes to cell-cell adhesions. A major recent advance has come with the realisation that cadherin adhesions are active mechanical structures, where cadherin serves as part of a mechanotransduction pathway by which junctions sense and elicit cellular responses to mechanical stimuli. Vinculin has emerged as an important element in cadherin mechanotransduction, a perspective that illuminates its role in cell-cell interactions. We now review its role as a cortical scaffold and its role in cadherin mechanotransduction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.