ArticleInternational journal of radiation oncology, biology, physics2013
Historical trends in the use of radiation therapy for pediatric cancers: 1973-2008.
Article in International journal of radiation oncology, biology, physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06443632 (WASPE Sleep Adjustment for Children Aged 0-4 Years Undergoing Radiation Therapy), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
WASPE Sleep Adjustment for Children Aged 0-4 Years Undergoing Radiation Therapy: A Prospective Randomized Controlled Phase II Clinical Trial
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Why are not all paediatric cancer patients treated with protons? A population-based report from Sweden, 2016-2023.Acta oncologica (Stockholm, Sweden) · 2025Article
- Trends in Radiation Use from 2004 to 2020 among Adolescents and Young Adults with Hodgkin Lymphoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Clinical Profile of Pediatric Oncology Patients Treated by Radiotherapy: A Retrospective Audit from a Tertiary Cancer Care Center in South India.South Asian journal of cancer · 2025Article
- Thyroid Cancer in Childhood Leukemia Survivors: A Systematic Review of the Incidence and Survival Outcomes.Journal of clinical medicine · 2025Review
- Image-guided targeting of mitochondrial metabolism sensitizes pediatric malignant rhabdoid tumors to low-dose radiotherapy.Science advances · 2025Article
- Temporal trends of subsequent central nervous system malignancies among survivors of childhood cancer.Journal of the National Cancer Institute · 2025Article
- Allies not enemies-creating a more empathetic and uplifting patient experience through technology and art.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Review
- Estimating proton beam therapy utilization and Investment in Thailand.Frontiers in public health · 2025Article
- Intraoperative radiation therapy for pediatric sarcomas and other solid tumors.Pediatric blood & cancer · 2024Article
- Establishment of Twinning Partnership to Improve Pediatric Radiotherapy Outcomes Globally.JCO global oncology · 2024Article
- Paediatric radiotherapy in the United Kingdom: an evolving subspecialty and a paradigm for integrated teamworking in oncology.The British journal of radiology · 2024Article
- The Landscape of Pediatric Radiation Oncology in Nigeria.JCO global oncology · 2024Review
- Article
- Proposal of a diagnostic algorithm for radiation-induced dropped head syndrome in long-term childhood cancer survivors based on a prospective study in a specialized clinical setting and a review of the literature.Journal of cancer research and clinical oncology · 2023Review
- The need for consensus on delineation and dose constraints of dentofacial structures in paediatric radiotherapy: Outcomes of a SIOP Europe survey.Clinical and translational radiation oncology · 2023Article
- Impact of proton therapy on the DNA damage induction and repair in hematopoietic stem and progenitor cells.Scientific reports · 2023Article
- The impact of radiotherapy on the hypothalamo-pituitary axis: old vs new radiotherapy techniques.Endocrine connections · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeThis study was undertaken to assess historical trends in the use of radiation therapy (RT) for pediatric cancers over the past 4 decades.
methodsThe National Cancer Institute's Surveillance, Epidemiology, and End Results database of the 9 original tumor registries (SEER-9) was queried to identify patients aged 0 to 19 years with acute lymphoblastic leukemia, acute myeloid leukemia, bone and joint cancer, cancer of the brain and nervous system, Hodgkin lymphoma, neuroblastoma, non-Hodgkin lymphoma, soft tissue cancer, Wilms tumor, or retinoblastoma from 1973 to 2008. Patients were grouped into 4-year time epochs. The number and percentage of patients who received RT as part of their initial treatment were calculated per epoch by each diagnosis group from 1973 to 2008.
resultsRT use for acute lymphoblastic leukemia, non-Hodgkin lymphoma, and retinoblastoma declined sharply from 57%, 57%, and 30% in 1973 to 1976 to 11%, 15%, and 2%, respectively, in 2005 to 2008. Similarly, smaller declines in RT use were also seen in brain cancer (70%-39%), bone cancer (41%-21%), Wilms tumor (75%-53%), and neuroblastoma (60%-25%). RT use curves for Wilms tumor and neuroblastoma were nonlinear with nadirs in 1993 to 1996 at 39% and 19%, respectively. There were minimal changes in RT use for Hodgkin lymphoma, soft tissue cancer, or acute myeloid leukemia, roughly stable at 72%, 40%, and 11%, respectively. Almost all patients treated with RT were given external beam RT exclusively. However, from 1985 to 2008, treatments involving brachytherapy, radioisotopes, or combination therapy increased in frequency, comprising 1.8%, 4.6%, and 11.9% of RT treatments in brain cancer, soft tissue cancer, and retinoblastoma, respectively.
conclusionsThe use of RT is declining over time in 7 of 10 pediatric cancer categories. A limitation of this study is a potential under-ascertainment of RT use in the SEER-9 database including the delayed use of RT.
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