Evidence map›Paper›PMID 23273858›Full record

ReviewInternational review of cell and molecular biology2013

New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.

Aiko Sada, Tudorita Tumbar

Abstract readReview
In one paragraph

Review in International review of cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Cell proliferation and differentiation during epidermis renewal.Journal of Zhejiang University. Science. B · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aiko SadaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
Tudorita Tumbar
Cornell University · US

Funding

Slowly cycling cells and hair follicle stem cellsR01AR053201 · NIAMS · CORNELL UNIVERSITY ITHACA · PI TUMBAR, TUDORITA · 2005 to 2014
$3.8M
NIAMS NIH HHS R01 AR053201NIAMS NIH HHS R01AR053201
6 · The paper itself

Abstract

Stem cells can self-renew and differentiate over extended periods of time. Understanding how stem cells acquire their fates is a central question in stem cell biology. Early work in Drosophila germ line and neuroblast showed that fate choice is achieved by strict asymmetric divisions that can generate each time one stem and one differentiated cell. More recent work suggests that during homeostasis, some stem cells can divide symmetrically to generate two differentiated cells or two identical stem cells to compensate for stem cell loss that occurred by direct differentiation or apoptosis. The interplay of all these factors ensures constant tissue regeneration and the maintenance of stem cell pool size. This interplay can be modeled as a population-deterministic dynamics that, at least in some systems, may be described as stochastic behavior. Here, we overview recent progress made on the characterization of stem cell dynamics in regenerative tissues.

Indexed as

AnimalsCaenorhabditis elegansCell DifferentiationCell DivisionDrosophilaFemaleHumansMaleModels, BiologicalRegenerationStem Cell NicheStem Cells

Identifiers

PMID23273858
PMCPMC5788169
OpenAlexW2396964934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.