Evidence map›Paper›PMID 23273695›Full record

ArticleJournal of vascular and interventional radiology : JVIR2013

Treatment of high-risk venous thrombosis patients using low-dose intraclot injections of recombinant tissue plasminogen activator and regional anticoagulation.

Richard Chang, John A Butman, Russell R Lonser, Richard M Sherry, Prakash K Pandalai, McDonald K Horne, Jay N Lozier

Registry-linked trialOpen access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00082355 (The Treatment of Deep Vein Thrombosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00082355 phase2completednot on this map

The Treatment of Deep Vein Thrombosis (DVT) of the Lower Extremities With "Low-Dose" Alteplase: a Pilot Study

TypeinterventionalSponsorRichard Chang, M.D.Ran2004 to 2014Enrolled30ConditionsAcute Deep Venous Thrombosis of the Lower ExtremityArmsAlteplase (Activase, Genentech)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Richard ChangRadiology and Imaging Sciences Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. rchang@cc.nih.gov
John A Butman
Russell R Lonser
Richard M Sherry
Prakash K Pandalai
McDonald K Horne
Jay N Lozier
National Institutes of Health · US

Funding

Treatment of Deep Vein Thrombosis of the Lower Extremities w/Low Dose AlteplaseZIACL010343 · CLC · CLINICAL CENTER · PI CHANG, RICHARD T · 2009 to 2014
$0k
Endothelial, Platelet, & Coagulation Factor Abnormalities in Abnormal HemostasisZIACL080014 · CLC · CLINICAL CENTER · PI LOZIER, JAY · 2009 to 2017
$0k
Evaluation of Fibrinolysis for Deep Vein ThrombosisZIACL080015 · CLC · CLINICAL CENTER · PI LOZIER, JAY · 2009 to 2014
$0k
Intramural NIH HHS Z99 CL999999Intramural NIH HHS ZIA CL010343
6 · The paper itself

Abstract

Seven patients with venous thrombosis and contraindications to traditional thrombolytic therapy, consisting of recent intracranial surgery, recent pineal or retroperitoneal hemorrhage, active genitourinary or gastrointestinal bleeding, epidural procedures, and impending surgery, were successfully treated with a modified thrombolytic regimen. To improve safety, prolonged continuous infusions of tissue plasminogen activator (tPA) was eliminated in favor of once-daily low-dose intraclot injections of tPA to minimize the amount and duration of tPA in the systemic circulation, and low-therapeutic or regional anticoagulation was used to reduce anticoagulant risks. These modifications may allow thrombolytic treatment for selected patients with severe venous thrombosis who are deemed to be at high risk.

Indexed as

AdultAgedAged, 80 and overAnticoagulantsDose-Response Relationship, DrugDrug Therapy, CombinationFemaleFibrinolytic AgentsHumansMaleMiddle AgedRecombinant ProteinsTissue Plasminogen ActivatorTreatment OutcomeVenous ThrombosisAnticoagulantsFibrinolytic AgentsRecombinant ProteinsTissue Plasminogen Activator

Identifiers

PMID23273695
PMCPMC3636547
OpenAlexW2140725649

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.