Evidence map›Paper›PMID 23273358›Full record

Trial reportAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics2013

Effectiveness of MI Paste Plus and PreviDent fluoride varnish for treatment of white spot lesions: a randomized controlled trial.

Greg J Huang, Brie Roloff-Chiang, Brian E Mills, Salma Shalchi, Charles Spiekerman, Anna M Korpak, Jeri L Starrett, Geoffrey M Greenlee, Ross J Drangsholt, Jack C Matunas

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 61 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 7 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02424097 phase4completednot on this map

MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2013 to 2016Enrolled40ConditionsDental White Spots, Dental CariesArmsCPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste, 1,100pm F-toothpaste and 0.5%NaF rinse
NCT05733676 narecruitingnot on this mapstarted 2023, after this paper: background citation

Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of AlbertaRan2023 to 2028Enrolled62ConditionsWhite Spot Lesions, Orthodontic Appliance Complication, Caries Arrested, Smooth Surface CariesArmsResin infiltration, Casein Phosphopeptide (CPP) - Amorphous Calcium Phosphate (ACP) - Fluoride
NCT05900817 nacompletednot on this mapstarted 2022, after this paper: background citation

Esthetic Management of Anterior Teeth Utilizing Two Micro Abrasion Treatments: Randomized Clinical Trial

TypeinterventionalSponsorBeni-Suef UniversityRan2022 to 2022Enrolled30ConditionsHypomineralization of EnamelArmsantivet, Oplsture
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 7 syntheses or guidelines pooled it, 158 citations in OpenAlex.

  1. Pooled it
  2. Self-assembling peptides for managing white spot lesions: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023
    Pooled it
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  6. [Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017
    Pooled it
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  12. Efficacy of PScientific reports · 2020
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Greg J HuangProfessor and chair, Department of Orthodontics, University of Washington, Seattle, WA 98195-7446, USA. ghuang@u.washington.edu
Brie Roloff-Chiang
Brian E Mills
Salma Shalchi
Charles Spiekerman
Anna M Korpak
Jeri L Starrett
Geoffrey M Greenlee
Ross J Drangsholt
Jack C Matunas
University of Washington · USBellevue College · US

Funding

Network Chair for the Pacific Northwest DPBRNU01DE016750 · NIDCR · UNIVERSITY OF WASHINGTON · PI DEROUEN, TIMOTHY A · 2005 to 2011
$11.1M
Data Coordinating Center for the Pacific Northwest DPBRNU01DE016752 · NIDCR · UNIVERSITY OF WASHINGTON · PI LEROUX, BRIAN GILBERT · 2005 to 2011
$6.8M
Institute of Translational Health SciencesTL1TR000422 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$2.1M
NCATS NIH HHS TL1 TR000422NIDCR NIH HHS U01 DE016750NIDCR NIH HHS U01 DE016752
6 · The paper itself

Abstract

introductionWhite spot lesions are a common sequela of orthodontic therapy. In this parallel-group randomized trial, we assessed the effectiveness of 2 agents commonly used to ameliorate white spot lesions compared with a normal home-care regimen.

methodsPatients aged 12 to 20 years were recruited from the offices of orthodontists and dentists who belonged to the Practice-based Research Collaborative in Evidence-based Dentistry network. The patients had their orthodontic appliances removed within the past 2 months and had at least 1 white spot lesion affecting their maxillary incisors. The subjects were randomized to 1 of 3 arms: (1) an 8-week regimen of MI Paste Plus (GC America, Alsip, Ill), (2) a single application of PreviDent fluoride varnish (Colgate Oral Pharmaceuticals, New York, NY), and (3) usual home care (control). Photographs were taken at enrollment and 8 weeks later. Two panels consisting of 5 dental professionals and 5 laypersons assessed the before-and-after pairs of photographs in a blinded fashion. Objective assessments and self-assessments were also performed.

resultsOne hundred fifteen subjects completed the study; 34 were assigned to the MI Paste Plus group, 40 to the fluoride varnish group, and 41 to the control group. The mean improvements assessed by the professional panel were 21%, 29%, and 27% in the MI Paste Plus, fluoride varnish, and control groups, respectively.The results from the lay panel were 29%, 31%, and 25%, respectively. Objective improvements in the surface affected were 16%, 25%, and 17%, respectively; self-assessments of improvement were 37% in all 3 groups. No assessments indicated significant differences between subjects in the active arms compared with the control arm.

conclusionsMI Paste Plus and PreviDent fluoride varnish do not appear to be more effective than normal home care for improving the appearance of white spot lesions over an 8-week period.

Indexed as

AdolescentCariostatic AgentsCaseinsChild, PreschoolDental CariesDrug SynergismFemaleFluorides, TopicalFluorineHumansMaleOintmentsOral HygieneOrthodontic AppliancesSingle-Blind MethodTreatment OutcomeCariostatic Agentscasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseinsFluorides, TopicalFluorineOintments

Identifiers

PMID23273358
PMCPMC4111089
OpenAlexW2039088418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.