ArticleJournal of psychosomatic research2013
Vulnerability to somatic symptoms of depression during interferon-alpha therapy for hepatitis C: a 16-week prospective study.
Article in Journal of psychosomatic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00252538 (Genetic and Biochemical Markers of Interferon-Induced Depression.), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic and Biochemical Markers of Interferon-Induced Depression.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa.European psychiatry : the journal of the Association of European Psychiatrists · 2021Pooled it
- Role of stress and early-life stress in the pathogeny of inflammatory bowel disease.Frontiers in neuroscience · 2024Review
- The role of the immune system in posttraumatic stress disorder.Translational psychiatry · 2022Review
- Social relationship quality, depression and inflammation: A cross-cultural longitudinal study in the United States and Tokyo, Japan.The International journal of social psychiatry · 2022Article
- Somatic pain associated with initiation of interferon-alpha (IFN-α) plus ribavirin (RBV) therapy in chronic HCV patients: A prospective study.Brain, behavior, & immunity - health · 2020Article
- Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?Clinical and experimental immunology · 2019Review
- S100B and Inflammatory Cytokine Levels in Blood as Potential Markers of Blood-Brain Barrier Damage and Psychiatric Impairment in Comorbid Hepatitis C Viral Infection and Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Article
- Therapeutic Strategies for Treatment of Inflammation-related Depression.Current neuropharmacology · 2018Review
- Imaging the Role of Inflammation in Mood and Anxiety-related Disorders.Current neuropharmacology · 2018Review
- The cortisol:C-reactive protein ratio and negative affect reactivity in depressed adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory.Drug and alcohol dependence · 2017Article
- Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C.Psychiatry investigation · 2017Article
- The mucosal immune system: master regulator of bidirectional gut-brain communications.Nature reviews. Gastroenterology & hepatology · 2017Review
- Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake.Neuropsychobiology · 2017Article
- Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Hepatitis C virus and non-Hodgkin's lymphomas: Meta-analysis of epidemiology data and therapy options.World journal of hepatology · 2016Review
- Psychiatric and substance use disorders co-morbidities and hepatitis C: Diagnostic and treatment implications.World journal of hepatology · 2015Review
- A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C.Journal of psychosomatic research · 2015Article
- Multi-analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection.Brain and behavior · 2014Article
- Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.Neuroscience · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThis study evaluated the distinctive clinical and biological manifestations of depressive symptom subtypes (i.e., cognitive-affective and somatic) in Veterans with hepatitis C viral infection (HCV) before and during interferon-alpha (IFN) based antiviral therapy.
methodsThirty-two Veterans with HCV and no prior history of IFN therapy were followed prospectively during the first 16weeks of therapy to evaluate depressive symptoms and to determine if baseline cytokine and serotonin levels predicted subsequent changes in depressive scores.
resultsIFN therapy resulted in a significant increase in total depressive symptoms from baseline (week 0) to week 16, with neurovegetative and somatic symptoms of depression including loss of appetite, fatigue and irritability increasing within the first two weeks of therapy and continuing to increase throughout IFN therapy. When depressive symptoms were evaluated using a two-factor (i.e., Cognitive-Affective and Somatic) model, the Cognitive-Affective factor score did not change significantly following IFN therapy initiation, while the Somatic factor score showed a significant increase from week 0 to week 16. Veterans with the largest increases in somatic symptoms from week 0 to week 2 had significantly higher levels of tumor necrosis factor-alpha (TNF-α) and lower levels of serotonin at baseline, as compared to Veterans with minimal or no increase in somatic symptoms.
conclusionSomatic symptoms of depression can be significantly exacerbated during IFN therapy and may be predicted by higher TNF-α levels and lower serotonin levels at baseline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.