ArticleBMC gastroenterology2012
Additional corpus biopsy enhances the detection of Helicobacter pylori infection in a background of gastritis with atrophy.
Article in BMC gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Clinical feasibility of deep learning-assisted classification of Helicobacter pylori infection in endoscopic imagery: a reader study.The Korean journal of internal medicine · 2026Article
- Review
- Article
- The second Irish Helicobacter pylori Working Group consensus for the diagnosis and treatment of Helicobacter pylori infection in adult patients in Ireland.European journal of gastroenterology & hepatology · 2024Article
- Intraprocedural gastric juice analysis as compared to rapid urease test for real-time detection ofWorld journal of gastroenterology · 2023Article
- Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance.Clinical microbiology reviews · 2022Review
- A prospective study for evaluating the effect of gastric targeted biopsy sampling with I-scan optical enhancement on the diagnostic yield of CLOtest forHealth science reports · 2022Article
- Addition of Nitazoxanide to Standard Clarithromycin Based Triple Therapy for 2 Weeks Effectively Eradicates Treatment-NaiveMiddle East journal of digestive diseases · 2022Article
- Direct detection of Helicobacter pylori from biopsies of patients in Lagos, Nigeria using real-time PCR-a pilot study.BMC research notes · 2021Article
- MALDI-TOF MS and 16S RNA Identification of Culturable Gastric Microbiota: Variability Associated with the Presence ofMicroorganisms · 2020Article
- Prevalence ofMedicina (Kaunas, Lithuania) · 2020Review
- Diagnostic methods for Helicobacter pylori infection: ideals, options, and limitations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Diagnosis of Helicobacter pylori infection : A short review.Wiener klinische Wochenschrift · 2018Review
- Colonization ofJGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Real-worldUnited European gastroenterology journal · 2016Article
- Limitations of urease test in diagnosis of pediatric Helicobacter pylori infection.World journal of clinical pediatrics · 2015Review
- Diagnosis of Helicobacter pylori infection: Current options and developments.World journal of gastroenterology · 2015Review
- A combined antral and corpus rapid urease testing protocol can increase diagnostic accuracy despite a low prevalence of Helicobacter pylori infection in patients undergoing routine gastroscopy.United European gastroenterology journal · 2015Article
- The use of a second biopsy from the gastric body for the detection of Helicobacter pylori using rapid urease test.Singapore medical journal · 2014Article
- Helicobacter pylori infection - recent developments in diagnosis.World journal of gastroenterology · 2014Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe best sites for biopsy-based tests to evaluate H. pylori infection in gastritis with atrophy are not well known. This study aimed to evaluate the site and sensitivity of biopsy-based tests in terms of degree of gastritis with atrophy.
methodsOne hundred and sixty-four (164) uninvestigated dyspepsia patients were enrolled. Biopsy-based tests (i.e., culture, histology Giemsa stain and rapid urease test) and non-invasive tests (anti-H. pylori IgG) were performed. The gold standard of H. pylori infection was defined according to previous criteria. The sensitivity, specificity, positive predictive rate and negative predictive rate of biopsy-based tests at the gastric antrum and body were calculated in terms of degree of gastritis with atrophy.
resultsThe prevalence rate of H. pylori infection in the 164 patients was 63.4%. Gastritis with atrophy was significantly higher at the antrum than at the body (76% vs. 31%; p<0.001). The sensitivity of biopsy-based test decreased when the degree of gastritis with atrophy increased regardless of biopsy site (for normal, mild, moderate, and severe gastritis with atrophy, the sensitivity of histology Giemsa stain was 100%, 100%, 88%, and 66%, respectively, and 100%, 97%, 91%, and 66%, respectively, for rapid urease test). In moderate to severe antrum or body gastritis with atrophy, additional corpus biopsy resulted in increased sensitivity to 16.67% compare to single antrum biopsy.
conclusionsIn moderate to severe gastritis with atrophy, biopsy-based test should include the corpus for avoiding false negative results.
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