ArticlePloS one2012
MicroRNAome and expression profile of developing tooth germ in miniature pigs.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Spatiotemporal Expression Patterns of Critical Genes Involved in FGF Signaling During Morphogenesis and Odontogenesis of Deciduous Molars in Miniature Pigs.International journal of medical sciences · 2022Article
- Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.Stem cells international · 2020Article
- Expression of BMP2/4/7 during the odontogenesis of deciduous molars in miniature pig embryos.Journal of molecular histology · 2018Article
- Expression and Regulation Profile of Mature MicroRNA in the Pig: Relevance to Xenotransplantation.BioMed research international · 2018Review
- Bicarbonate Transport During Enamel Maturation.Calcified tissue international · 2017Review
- MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways-Novel Insight into the Origins of Enamel Pathologies.Scientific reports · 2017Article
- Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs.BMC genomics · 2016Article
- Identification of differential microRNA expression during tooth morphogenesis in the heterodont dentition of miniature pigs, SusScrofa.BMC developmental biology · 2015Article
- MicroRNA 665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms.Molecular and cellular biology · 2015Article
- Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis.BMC genomics · 2014Article
- Identification and characterization of novel serum microRNA candidates from deep sequencing in cervical cancer patients.Scientific reports · 2014Article
- Construction of a cDNA library for miniature pig mandibular deciduous molars.BMC developmental biology · 2014Article
- Transcriptome analysis during seed germination of elite Chinese bread wheat cultivar Jimai 20.BMC plant biology · 2014Article
- Article
- Systems biology approach to the dissection of the complexity of regulatory networks in the S. scrofa cardiocirculatory system.International journal of molecular sciences · 2013Article
- MicroRNA expression profiling of the porcine developing hypothalamus and pituitary tissue.International journal of molecular sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) play important roles in the regulation of rodent tooth development, but little is known about their role in tooth development in large mammals. We identified 637 unique miRNA sequences in a large-scale screen for miRNA expression profiles in the developing lower deciduous molars of miniature pigs (Sus scrofa) using Illumina Solexa deep sequencing. These candidate miRNAs and another 105 known Sus scrofa miRNAs were included in the custom-designed microarray and used to analyze the miRNA expression profile in the bud, cap, early bell, and late bell stages of tooth development. Microarray analysis revealed 166 transcripts that were differentially expressed in the four stages. Bioinformatic analysis identified 18 key miRNAs, including let-7f, miR-128, miR-200b, and miR-200c, that might play key roles in tooth development. Taken together, our results not only identified the specific microRNAome and expression profile in developing lower deciduous molars of the miniature pig, but they also provided useful information for investigating the molecular mechanism of tooth development in the miniature pig.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.