ArticlePloS one2012
Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Optical Coherence Tomography Imaging and Angiography of Skull Base Tumors Presenting as a Middle Ear Mass in Clinic.Diagnostics (Basel, Switzerland) · 2025Article
- Multimodal Optical Imaging to Investigate Spatiotemporal Changes in Cerebrovascular Function in AUDA Treatment of Acute Ischemic Stroke.Frontiers in cellular neuroscience · 2021Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Monitoring blood-flow in the mouse cochlea using an endoscopic laser speckle contrast imaging system.PloS one · 2018Article
- Two-photon microscopy allows imaging and characterization of cochlear microvasculature in vivo.BioMed research international · 2015Article
- Multimodal optical imaging can reveal changes in microcirculation and tissue oxygenation during skin wound healing.Lasers in surgery and medicine · 2014Article
- Thin and open vessel windows for intra-vital fluorescence imaging of murine cochlear blood flow.Hearing research · 2014Article
- Analysis of cross-sectional image filters for evaluating nonaveraged optical microangiography images.Applied optics · 2014Article
- Assessment of microcirculation dynamics during cutaneous wound healing phases in vivo using optical microangiography.Journal of biomedical optics · 2014Article
- Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry.Quantitative imaging in medicine and surgery · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A synchronized dual-wavelength laser speckle contrast imaging (DWLSCI) system and a Doppler optical microangiography (DOMAG) system was developed to determine several ischemic parameters in the cochlea due to a systemic hypoxic challenge. DWLSCI can obtain two-dimensional data, and was used to determine the relative changes in cochlear blood flow, and change in the concentrations of oxyhemoglobin (HbO), deoxyhemoglobin (Hb) and total hemoglobin (HbT) in mice. DOMAG can obtain three-dimensional data, and was used to determine the changes in cochlear blood flow with single vessel resolution. It was demonstrated that during a hypoxic challenge there was an increase in the concentrations of Hb, a decrease in the concentrations of HbO and cochlear blood flow, and a slight decrease in the concentration of HbT. Also, the rate of change in the concentrations of Hb and HbO was quantified during and after the hypoxic challenge. The ability to simultaneously measure these ischemic parameters with high spatio-temporal resolution will allow the detailed quantitative analysis of several hearing disorders, and will be useful for diagnosing and developing treatments.
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