ArticlePloS one2012
CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection.Scientific reports · 2025Article
- Article
- Killing the competition: a theoretical framework for liver-stage malaria.Open biology · 2022Article
- Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.EMBO molecular medicine · 2021Article
- Identification of Plasmodium falciparum circumsporozoite protein-specific CD8+ T cell epitopes in a malaria exposed population.PloS one · 2020Article
- Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine.Frontiers in cellular and infection microbiology · 2017Review
- Protective immunity to liver-stage malaria.Clinical & translational immunology · 2016Review
- Defining rules of CD8(+) T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice.Malaria journal · 2016Article
- Tailoring a Combination Preerythrocytic Malaria Vaccine.Infection and immunity · 2015Article
- Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites.PLoS pathogens · 2015Article
- Plasmodium cellular effector mechanisms and the hepatic microenvironment.Frontiers in microbiology · 2015Review
- Antigen export during liver infection of the malaria parasite augments protective immunity.mBio · 2014Article
- Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites.Frontiers in microbiology · 2014Review
- Priming of CD8(+) T Cell Responses to Liver Stage Malaria Parasite Antigens.Frontiers in immunology · 2014Review
- Article
- Immune surveillance by the liver.Nature immunology · 2013Review
- A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One target of protective immunity against the Plasmodium liver stage in BALB/c mice is represented by the circumsporozoite protein (CSP), and mainly involves its recognition by IFN-γ producing specific CD8+T-cells. In a previous in vitro study we showed that primary hepatocytes from BALB/c mice process Plasmodium berghei (Pb) CSP (PbCSP) and present CSP-derived peptides to specific H-2k(d) restricted CD8+T-cells with subsequent killing of the presenting cells. We now extend these observations to an in vivo infection model in which infected hepatocytes and antigen specific T-cell clones are transferred into recipient mice inducing protection from sporozoite (SPZ) challenge. In addition, using a similar protocol, we suggest the capacity of hepatocytes in priming of naïve T-cells to provide protection, as further confirmed by induction of protection after depletion of cross-presenting dendritic cells (DCs) by cytochrome c (cyt c) treatment or using traversal deficient parasites. Our results clearly show that hepatocytes present Plasmodium CSP to specific-primed CD8+T-cells, and could also prime naïve T-cells, leading to protection from infection. These results could contribute to a better understanding of liver stage immune response and design of malaria vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.