Trial reportPloS one2012
Retinal nerve fibre layer thinning in patients with clinically isolated optic neuritis and early treatment with interferon-beta.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Fingolimod after a first unilateral episode of acute optic neuritis (MOVING) - preliminary results from a randomized, rater-blind, active-controlled, phase 2 trial.BMC neurology · 2020Trial
- Neuroprotective Effects of Novel Treatments on Acute Optic Neuritis-A Meta-Analysis.Biomedicines · 2022Article
- Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis.Therapeutic advances in neurological disorders · 2021Article
- Defining Disease Activity and Response to Therapy in MS.Current treatment options in neurology · 2017Review
- Longitudinal time-domain optic coherence study of retinal nerve fiber layer in IFNβ-treated and untreated multiple sclerosis patients.Experimental and therapeutic medicine · 2016Article
- Acute optic neuritis: Unmet clinical needs and model for new therapies.Neurology(R) neuroimmunology & neuroinflammation · 2015Review
- Behaviour of disc oedema during and after amiodarone optic neuropathy: case report.Journal of clinical and diagnostic research : JCDR · 2014Article
- [Clinically isolated syndrome].Der Nervenarzt · 2013Review
- Prospective study on retinal nerve fibre layer thickness changes in isolated unilateral retrobulbar optic neuritis.TheScientificWorldJournal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptic neuritis is associated with neurodegeneration leading to chronic impairment of visual functions.
objectiveThis study investigated whether early treatment with interferon beta (IFN-β) slows retinal nerve fibre layer (RNFL) thinning in clinically isolated optic neuritis.
methodsTwenty patients with optic neuritis and visual acuity decreased to ≤0.5 (decimal system) were included into this prospective, open-label, parallel group 4-month observation. After methylprednisolone pulse therapy, 10 patients received IFN-β from week 2 onwards. This group was compared to 10 patients free of any disease modifying treatment (DMT). The parameter of interest was change in RNFL thickness assessed at baseline and at weeks 4, 8, and 16. Changes in visual acuity, visual field, and visual evoked potentials (VEPs) served as additional outcome parameters.
resultsRNFL thinning did not differ between the groups with a mean reduction of 9.80±2.80 µm in IFN-β-treated patients (±SD) vs. 12.44±5.79 µm in patients who did not receive DMT (baseline non-affected eye minus affected eye at week 16; p = 0.67, t-test, 95% confidence interval: -15.77 to 10.48). Parameters of visual function did not show any differences between the groups either.
conclusionsIn isolated optic neuritis, early IFN-β treatment did not influence RNFL thinning nor had it any effect on recovery of visual functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.