ArticlePloS one2012
Effects of enriched environment on COX-2, leptin and eicosanoids in a mouse model of breast cancer.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- The effects of environmental enrichment on skin barrier recovery in humans: a randomised trial.Scientific reports · 2020Trial
- Photodynamic therapy mediated by a selective nanoemulsion for breast cancer treatment: in vitro and in vivo evaluation.Discover nano · 2026Article
- Evaluation of silver nitroprusside nanoparticles: selective toxicity against MCF-7 cells and in vivo antitumor activity.Discover nano · 2025Article
- Long-Term High-Fat Diet Limits the Protective Effect of Spontaneous Physical Activity on Mammary Carcinogenesis.International journal of molecular sciences · 2024Article
- New insight of square stepping exercise in immune fine-tuning for anticipating emerging pandemics.Animal cells and systems · 2024Review
- Effects of different environmental intervention durations on the intestinal mucosal barrier and the brain-gut axis in rats with colorectal cancer.Scientific reports · 2022Article
- Psychological distress and eustress in cancer and cancer treatment: Advances and perspectives.Science advances · 2022Review
- Early Social Enrichment Modulates Tumor Progression and p53 Expression in Adult Mice.Biomolecules · 2022Article
- Article
- Vitamin D supplementation associated with physical exercise promotes a tolerogenic immune environment without effect on mammary tumour growth in C57BL/6 mice.European journal of nutrition · 2021Article
- An Enriched Environment Alters DNA Repair and Inflammatory Responses After Radiation Exposure.Frontiers in immunology · 2021Article
- EO771, is it a well-characterized cell line for mouse mammary cancer model? Limit and uncertainty.Cancer medicine · 2020Review
- Maternal obesity increases offspring's mammary cancer recurrence and impairs tumor immune response.Endocrine-related cancer · 2020Article
- A simplified enriched environment increases body temperature and suppresses cancer progression in mice.Experimental animals · 2020Article
- Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?Frontiers in neuroscience · 2020Review
- EO771, the first luminal B mammary cancer cell line from C57BL/6 mice.Cancer cell international · 2020Article
- Environmental enrichment improves metabolic and behavioral health in the BTBR mouse model of autism.Psychoneuroendocrinology · 2020Article
- Anticancer activity of emodin is associated with downregulation of CD155.International immunopharmacology · 2019Article
- Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclooxygenase-2 (COX-2) and adipokines have been implicated in breast cancer. This study investigated a possible link between COX-2 and adipokines in the development of mammary tumors. A model of environmental enrichment (EE), known to reduce tumor growth was used for a syngeneic murine model of mammary carcinoma. 3-week-old, female C57BL/6 mice were housed in standard environment (SE) or EE cages for 9 weeks and transplanted orthotopically with syngeneic EO771 adenocarcinoma cells into the right inguinal mammary fat pad. EE housing influenced mammary gland development with a decrease in COX-2 expressing cells and enhanced side-branching and advanced development of alveolar structures of the mammary gland. Tumor volume and weight were decreased in EE housed mice and were associated with a reduction in COX-2 and Ki67 levels, and an increase in caspase-3 levels. In tumors of SE mice, high COX-2 expression correlated with enhanced leptin detection. Non-tumor-bearing EE mice showed a significant increase in adiponectin levels but no change in those of leptin, F(2)-isoprostanes, PGF(2α), IL-6, TNF-α, PAI-1, and MCP-1 levels. Both tumor-bearing groups (SE and EE housing) had increased resistin, IL-6, TNF-α, PAI-1 and MCP-1 levels irrespective of the different housing environment demonstrating higher inflammatory response due to the presence of the tumor. This study demonstrates that EE housing influenced normal mammary gland development and inhibited mammary tumor growth resulting in a marked decrease in intratumoral COX-2 activity and an increase in the plasma ratio of adiponectin/leptin levels.
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Registered trials
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