ArticlePloS one2012
Suites of terpene synthases explain differential terpenoid production in ginger and turmeric tissues.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Characterization of the Flavor Profiles of Fresh and Hot-Air-Dried Ginger (Foods (Basel, Switzerland) · 2026Article
- Genetically Encoded Detection of Biosynthetic Protease Inhibitors.ACS synthetic biology · 2023Article
- Genome sequencing of turmeric provides evolutionary insights into its medicinal properties.Communications biology · 2021Article
- Variable Secondary Metabolite Profiles Across Cultivars ofFrontiers in pharmacology · 2021Article
- Identification and Functional Characterization of Tissue-Specific Terpene Synthases inInternational journal of molecular sciences · 2020Article
- An integrated strategy to identify genes responsible for sesquiterpene biosynthesis in turmeric.Plant molecular biology · 2019Article
- Gene Networks Underlying Cannabinoid and Terpenoid Accumulation in Cannabis.Plant physiology · 2019Article
- GC-MS Analysis of the Composition of the Essential Oil from Dendranthema indicum Var. Aromaticum Using Three Extraction Methods and Two Columns.Molecules (Basel, Switzerland) · 2018Article
- Four terpene synthases contribute to the generation of chemotypes in tea tree (Melaleuca alternifolia).BMC plant biology · 2017Article
- Caryolan-1-ol, an antifungal volatile produced byOpen biology · 2017Article
- Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.The Journal of antibiotics · 2016Article
- Article
- Ginger from ancient times to the new outlook.Jundishapur journal of natural pharmaceutical products · 2015Review
- Characterization of two monoterpene synthases involved in floral scent formation in Hedychium coronarium.Planta · 2014Article
- Therapeutic implications of curcumin in the prevention of diabetic retinopathy via modulation of anti-oxidant activity and genetic pathways.International journal of physiology, pathophysiology and pharmacology · 2013Review
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2 authors at 1 institution in 1 country.
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Abstract
The essential oils of ginger (Zingiber officinale) and turmeric (Curcuma longa) contain a large variety of terpenoids, some of which possess anticancer, antiulcer, and antioxidant properties. Despite their importance, only four terpene synthases have been identified from the Zingiberaceae family: (+)-germacrene D synthase and (S)-β-bisabolene synthase from ginger rhizome, and α-humulene synthase and β-eudesmol synthase from shampoo ginger (Zingiber zerumbet) rhizome. We report the identification of 25 mono- and 18 sesquiterpene synthases from ginger and turmeric, with 13 and 11, respectively, being functionally characterized. Novel terpene synthases, (-)-caryolan-1-ol synthase and α-zingiberene/β-sesquiphellandrene synthase, which is responsible for formation of the major sesquiterpenoids in ginger and turmeric rhizomes, were also discovered. These suites of enzymes are responsible for formation of the majority of the terpenoids present in these two plants. Structures of several were modeled, and a comparison of sets of paralogs suggests how the terpene synthases in ginger and turmeric evolved. The most abundant and most important sesquiterpenoids in turmeric rhizomes, (+)-α-turmerone and (+)-β-turmerone, are produced from (-)-α-zingiberene and (-)-β-sesquiphellandrene, respectively, via α-zingiberene/β-sesquiphellandrene oxidase and a still unidentified dehydrogenase.
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