SynthesisPloS one2012
Prediction of poor outcome in patients with acute liver failure-systematic review of prediction models.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prediction Models and Their External Validation Studies for Mortality of Patients with Acute Kidney Injury: A Systematic Review.PloS one · 2017Pooled it
- Practical Utility of Serum Ammonia in Children With Acute Liver Failure: A Biomarker of Outcome.Transplantation direct · 2025Article
- Improved mortality prediction for pediatric acute liver failure using dynamic prediction strategy.Journal of pediatric gastroenterology and nutrition · 2024Article
- Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients.Critical care (London, England) · 2022Review
- The Role of Predictive Models in the Assessment of the Poor Outcomes in Pediatric Acute Liver Failure.Journal of clinical medicine · 2022Article
- Comparison of transient elastography and Model for End-Stage Liver Disease-sodium to Model for End-Stage Liver Disease-sodium alone to predict mortality and liver transplantation.European journal of gastroenterology & hepatology · 2021Article
- Is Artificial Intelligence Better Than Human Clinicians in Predicting Patient Outcomes?Journal of medical Internet research · 2020Article
- Prediction Tools for Psychiatric Adverse Effects After Levetiracetam Prescription.JAMA neurology · 2019Article
- TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.Science translational medicine · 2018Article
- Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report.BMC anesthesiology · 2018Article
- High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair.Frontiers in physiology · 2018Article
- Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance.Liver international : official journal of the International Association for the Study of the Liver · 2017Article
- Development of a Model to Predict Transplant-free Survival of Patients With Acute Liver Failure.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2016Article
- Overview on acute-on-chronic liver failure.Frontiers of medicine · 2016Review
- Clinical profile, natural history, and predictors of mortality in patients with acute-on-chronic liver failure (ACLF).Wiener klinische Wochenschrift · 2015Observational
- Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure.World journal of gastroenterology · 2014Article
- Acute liver failure and liver transplantation.Intractable & rare diseases research · 2013Review
- The utility of the SOFA score for predicting mortality in critically ill cirrhotic patients receiving liver transplantation.Critical care (London, England) · 2013Article
- Causes and outcomes of acute liver failure in China.PloS one · 2013Article
- Development of a prognostic model for pediatric acute liver failure in a Brazilian center.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute liver failure is a rare disease with high mortality and liver transplantation is the only life saving therapy. Accurate prognosis of ALF is crucial for proper intervention.
aimTo identify and characterize newly developed prognostic models of mortality for ALF patients, assess study quality, identify important variables and provide recommendations for the development of improved models in the future.
methodsThe online databases MEDLINE® (1950-2012) and EMBASE® (1980-2012) were searched for English-language articles that reported original data from clinical trials or observational studies on prognostic models in ALF patients. Studies were included if they developed a new model or modified existing prognostic models. The studies were evaluated based on an existing framework for scoring the methodological and reporting quality of prognostic models.
resultsTwenty studies were included, of which 18 reported on newly developed models, 1 on modification of the Kings College Criteria (KCC) and 1 on the Model for End-Stage Liver Disease (MELD). Ten studies compared the newly developed models to previously existing models (e.g. KCC); they all reported that the new models were superior. In the 12-point methodological quality score, only one study scored full points. On the 38-point reporting score, no study scored full points. There was a general lack of reporting on missing values. In addition, none of the studies used performance measures for calibration and accuracy (e.g. Hosmer-Lemeshow statistics, Brier score), and only 5 studies used the AUC as a measure of discrimination.
conclusionsThere are many studies on prognostic models for ALF but they show methodological and reporting limitations. Future studies could be improved by better reporting and handling of missing data, the inclusion of model calibration aspects, use of absolute risk measures, explicit considerations for variable selection, the use of a more extensive set of reference models and more thorough validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.