ArticleThe Journal of biological chemistry2013
Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Ichthyosis Prematurity Syndrome: A Systematic Review of the Literature.Pediatric dermatologyPooled it
- Detailed composition of wax esters in mouse sebum and the involvement of FAR2 and AWAT2.iScience · 2026Article
- The metabolic underpinnings of sebaceous lipogenesis.Communications biology · 2025Review
- Atrophic meibomian gland dysfunction induced by eyelid margin cryotherapy with liquid nitrogen.Scientific reports · 2025Article
- First documented case of ichthyosis prematurity syndrome in Iraq: A case report with literature review.Radiology case reports · 2024Article
- Elongation of Very Long-Chain Fatty Acids (ELOVL) in Atopic Dermatitis and the Cutaneous Adverse Effect AGEP of Drugs.International journal of molecular sciences · 2024Review
- A New Organotypic 3D Slice Culture ofInternational journal of molecular sciences · 2022Article
- Mouse models in studies on the etiology of evaporative dry eye disease.Experimental eye research · 2022Review
- Application of Animal Models in Interpreting Dry Eye Disease.Frontiers in medicine · 2022Review
- Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols.Scientific reports · 2019Article
- Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.The American journal of pathology · 2018Article
- Linear ion-trap MSJournal of lipid research · 2017Article
- Genetically modified laboratory mice with sebaceous glands abnormalities.Cellular and molecular life sciences : CMLS · 2016Review
- Need for Animal Models of Meibomian Gland Dysfunction.Ophthalmology and therapy · 2016Article
- Novel insights into the behavioral analysis of mice subjected to the forced-swim test.Translational psychiatry · 2015Article
- Fatty acid transport protein 1 can compensate for fatty acid transport protein 4 in the developing mouse epidermis.The Journal of investigative dermatology · 2015Article
- Fatty acid transporters in skin development, function and disease.Biochimica et biophysica acta · 2014Review
- Biophysical and morphological evaluation of human normal and dry eye meibum using hot stage polarized light microscopy.Investigative ophthalmology & visual science · 2014Article
- Acyl-CoA metabolism and partitioning.Annual review of nutrition · 2014Review
- Meibomian gland development: Where, when and how?Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Fatty acid transport protein 4 (FATP4) is one of a family of six transmembrane proteins that facilitate long- and very long-chain fatty acid uptake. FATP4 is expressed in several tissues, including skin. Mutations in human SLC27A4, which encodes FATP4, cause ichthyosis prematurity syndrome, characterized by a thick desquamating epidermis and premature birth. Mice lacking FATP4, which genetically model the human disease, are born with tight, thick skin and a defective skin barrier; they die neonatally due to dehydration and restricted movements. Both the skin phenotype and the lethality are rescued by transgene expression of FATP4 in suprabasal keratinocytes. Sebaceous glands in Fatp4 null skin grafted onto nude mice were found to be dystrophic and enwrapped by thick layers of epithelial cells. Consistent with these results, transgene-rescued Fatp4 null mice showed a subnormal level of FATP4 expression in sebocytes and exhibited abnormal development of both sebaceous glands and meibomian glands, specialized sebaceous glands of the eyelids. Sebum from these mice contained a reduced level of type II diester wax, a major mouse sebum lipid species, and showed perturbations in mass spectrometric profiles of diester wax and cholesteryl ester species. In addition, these mice showed an impaired ability to repel water and regulate body temperature after water immersion. Taken together, our results suggest that FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum, likely by regulating the trafficking of fatty acids necessary for proper synthesis of sebum lipids.
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Registered trials
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