ArticleNature communications2012
Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
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- Structural Correlates of CA2 and CA3 Pyramidal Cell Activity in Freely-Moving Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Diverse synaptic and dendritic mechanisms of complex spike burst generation in hippocampal CA3 pyramidal cells.Nature communications · 2019Article
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- Modeling driver cells in developing neuronal networks.PLoS computational biology · 2018Article
- Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia.Nature neuroscience · 2018Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early postnatal stages is minimal. However, without fast GABAergic transmission, a different situation may prevail. In the adult CA3, blocking fast GABAergic transmission induces the generation of network bursts that can be triggered by the stimulation of single pyramidal neurons. Here we revisit the network function of CA3 glutamatergic neurons from a developmental viewpoint, without fast GABAergic transmission. We uncover a sub-population of early-generated glutamatergic neurons that impacts network dynamics when stimulated in the juvenile hippocampus. Additionally, this population displays characteristic morpho-physiological features in the juvenile and adult hippocampus. Therefore, the apparently homogeneous glutamatergic cell population likely displays a morpho-functional diversity rooted in temporal embryonic origins.
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