Evidence map›Paper›PMID 23271614›Full record

ArticleEuropean journal of nutrition2013

Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study).

Elizabeth A Williams, Mark Welfare, Alison Spiers, Marilyn H Hill, Wendy Bal, Eileen R Gibney, Yvonne Duckworth, Hilary J Powers, John C Mathers

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In one paragraph

Article in European journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Elizabeth A WilliamsHuman Nutrition Unit, Department of Oncology, Faculty of Medicine, Dentistry and Health Sciences, University of Sheffield, Sheffield, S10 2RX, UK, e.a.williams@sheffield.ac.uk.
Mark Welfare
Alison Spiers
Marilyn H Hill
Wendy Bal
Eileen R Gibney
Yvonne Duckworth
Hilary J Powers
John C Mathers
University of Sheffield · GBNewcastle Hospitals - Campus for Ageing and Vitality · GBNewcastle University · GBNorth Tyneside General Hospital · GBUniversity College Dublin · IE

Funding

Medical Research Council G0700718
6 · The paper itself

Abstract

BACKGROUND/

objectivesFolate has been strongly implicated in the aetiology of colorectal cancer. However, the relationship between dietary folate intake, rectal mucosal folate status and colorectal cancer risk is uncertain. The study aimed to estimate nutrient intakes and measure systemic folate status and rectal mucosal folate concentration in people at differential risk of developing colorectal cancer.

methodsTwo hundred and twenty-eight individuals were recruited from gastroenterology clinics and subdivided into three patient groups: untreated colorectal cancer (n = 43), adenomatous polyps (n = 90) or normal bowel (n = 95). Biopsies from macroscopically normal rectal mucosa and blood were collected and used for the measurement of rectal mucosal 5-methyltetrahydrofolate (5-MeTHF) and systemic markers of folate status, respectively. Nutrient intake was estimated using a validated food frequency questionnaire.

resultsDietary intake variables, plasma 5-MeTHF and red cell folate and plasma homocysteine concentrations were similar in all three subject groups and 95% CI fell within normal range for each variable. Rectal mucosal 5-MeTHF concentration was higher in the normal mucosa of adenomatous polyp patients than in normal subjects (P = 0.055). Rectal mucosal 5-MeTHF was associated significantly with plasma folate (P < 0.001, r = 0.294), red cell folate (P = 0.014, r = 0.305), plasma homocysteine (P = 0.017, r = -0.163) and dietary folate intake (P = 0.036, r = 0.152).

conclusionsThis study demonstrates adequate folate status of patients attending gastroenterology clinics for the investigation of bowel symptoms, with no significant difference in dietary intakes or systemic folate status indices according to diagnosis. Rectal mucosal 5-MeTHF concentrations were elevated in adenomatous polyp patients, but failed to reach significance. Further studies are required to determine the biological significance of this observation.

Indexed as

DietCohort StudiesColorectal NeoplasmsErythrocytesFemaleFolic AcidGlutathione ReductaseHomocysteineHumansIntestinal MucosaMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedNutritional StatusNutrition AssessmentRisk Factors5-methyltetrahydrofolateFolic AcidGlutathione ReductaseHomocysteineMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanTetrahydrofolatesVitamin B 12

Identifiers

PMID23271614
OpenAlexW2066172822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.