Evidence map›Paper›PMID 23271451›Full record

ReviewPflugers Archiv : European journal of physiology2013

Probing neuronal activities with genetically encoded optical indicators: from a historical to a forward-looking perspective.

Hiroki Mutoh, Thomas Knöpfel

Abstract readHistorical ArticleReview
PubMed Publisher
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021
    Review
  2. Review
  3. Genetically Encoded Voltage Indicators in Circulation Research.International journal of molecular sciences · 2015
    Review
  4. Article
  5. Cardiac applications of optogenetics.Progress in biophysics and molecular biology · 2014
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hiroki MutohRIKEN Brain Science Institute, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
Thomas Knöpfel

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optical imaging has a long history in physiology and in neurophysiology in particular. Over the past 15 years or so, new methodologies have emerged that combine genetic engineering with light-based imaging methods. This merger has resulted in a tool box of genetically encoded optical indicators that enable nondestructive and long-lasting monitoring of neuronal activities at the cellular, circuit, and system level. This review describes the historical roots and fundamental concepts underlying these new approaches, evaluates current progress in this field, and concludes with a forward-looking perspective on current work and potential future developments in this field.

Indexed as

AnimalsHistory, 20th CenturyHumansIon ChannelsLuminescent ProteinsMembrane PotentialsNeuroimagingNeuronsOptical ImagingOptogeneticsRecombinant Fusion ProteinsIon ChannelsLuminescent ProteinsRecombinant Fusion Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.