ArticlePediatric radiology2013
Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children.
Article in Pediatric radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04523584 (Ultrasound Quantification of Liver Fat), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultrasound Quantification of Liver Fat
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The diagnostic performance of shear-wave elastography for liver fibrosis in children and adolescents: A systematic review and diagnostic meta-analysis.European radiology · 2018Pooled it
- Virtual Touch™ Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance.Applied health economics and health policy · 2017Pooled it
- Acoustic radiation force impulse (ARFI) elastography for detection of renal damage in children.Pediatric radiology · 2015Trial
- Non-invasive screening for liver fibrosis by acoustic radiation force impulse in patients with ciliopathies.Scientific reports · 2025Article
- Evaluation of Hepatic Shear Wave Elastography to Assess Liver Fibrosis in Biliary Atresia Patients and Its Correlation with Liver Histology and Surgical Outcomes: A Prospective Observational Study.The Indian journal of radiology & imaging · 2024Article
- Accuracy of a sequential algorithm based on FIB-4 and ELF to identify high-risk advanced liver fibrosis at the primary care level.Internal and emergency medicine · 2024Article
- Post-hepatoportoenterostomy Acoustic Radiation Force Impulse Elastography to Predict Two-year Outcome of Biliary Atresia.Journal of clinical and translational hepatology · 2023Article
- Article
- Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy.Clinical and experimental pediatrics · 2023Article
- Noninvasive Prediction of Advanced Fibrosis in Pediatric Liver Disease-Discriminatory Performance of 2D Shear Wave Elastography, Transient Elastography and Magnetic Resonance Elastography in Comparison to Histopathology.Diagnostics (Basel, Switzerland) · 2022Article
- Diagnostic Efficacy of Advanced Ultrasonography Imaging Techniques in Infants with Biliary Atresia (BA): A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2022Review
- Cystic fibrosis and noninvasive liver fibrosis assessment methods in children.Pediatric research · 2022Article
- A tailored passive driver for liver MRE in pediatric patients.Frontiers in pediatrics · 2022Article
- Acoustic radiation force impulse imaging: normal values of spleen stiffness in healthy children.Pediatric radiology · 2021Article
- Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers.Scientific reports · 2020Article
- Bidimensional shear-wave elastography for assessing liver fibrosis in children: a proposal of reference values that correlate with the histopathological Knodell-Ishak score.Pediatric radiology · 2020Observational
- Shear wave elastography correlates with liver fibrosis scores in pediatric patients with liver disease.Pediatric radiology · 2019Article
- The role of elastography in the assessment of chronic liver disease in children.African health sciences · 2019Article
- Performance of two--dimensional ultrasound shear wave elastography: reference values of normal liver stiffness in children.Pediatric radiology · 2019Article
- Hepatitis C virus infection in children in the era of direct-acting antiviral.World journal of gastroenterology · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcoustic radiation force impulse (ARFI) imaging) is correlated with histopathological findings using METAVIR and semiquantitative scoring system (SSS) criteria for liver fibrosis.
objectiveTo compare acoustic radiation force impulse imaging with biopsy results in the evaluation of liver fibrosis in children. MATERIALS AND
methodsChildren with chronic liver disease and healthy children underwent acoustic radiation force impulse imaging liver measurements. ARFI gives a shear-wave velocity corresponding to tissue elasticity. In 39 children with liver disease, the values obtained were correlated with biopsy results. Receiver-operating characteristic (ROC) curves were used to determine the reliability of ARFI in estimating liver fibrosis in children.
resultsARFI mean value was 1.12 in the healthy group and 1.99 in children with chronic liver disease. ROC curves show that an ARFI cutoff of 1.34 m/s is predictive of both METAVIR and SSS scores with a sensitivity of SSS > 2:0.85; METAVIR > F0:0.82. A cutoff of 2 m/s yielded a sensitivity of 100% to detect SSS > 4 or METAVIR > F2.
conclusionAcoustic radiation force impulse imaging is a reliable, noninvasive and rapid method to estimate moderate to severe liver fibrosis in children. It might prove useful to clinicians for fibrosis monitoring in children with liver disease and postpone the time of liver biopsy.
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