ArticleInternational journal of molecular sciences2012
Ultraviolet B (UVB) irradiation-induced apoptosis in various cell lineages in vitro.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Single or Daily Application of Topical Curcumin Prevents Ultraviolet B-Induced Apoptosis in Mice.Molecules (Basel, Switzerland) · 2023Trial
- UVB photoprotection by thiourea and (thio)semicarbazone derivatives: cellular and molecular evidence.Molecular biology reports · 2026Article
- Early ultraviolet exposure disrupts late dorsal fin skeletal development in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Photoreductive Degradation of Fe(III)-Catechol Crosslinked Hydrogels under Visible Light.Chemistry, an Asian journal · 2026Article
- Article
- Exploring the Surface: Sampling of Potential Skin Cancer Biomarkers Kynurenine and Tryptophan, Studied on 3D Melanocyte and Melanoma Models.Biomolecules · 2024Article
- Finding a Direct Method for a Dynamic Process: The DD (Direct and Dynamic) Cell-Tox Method.International journal of molecular sciences · 2024Article
- Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen species.Journal of ginseng research · 2024Article
- Cytotoxicity, Differentiation, and Biocompatibility of Root-End Filling: A Comprehensive Study.Biomimetics (Basel, Switzerland) · 2023Article
- Protective Effect of Flavonoids from Mulberry Leaf on AAPH-Induced Oxidative Damage in Sheep Erythrocytes.Molecules (Basel, Switzerland) · 2022Article
- Isolation, characterization and anti-UVB irradiation activity of an extracellular polysaccharide produced byHeliyon · 2022Article
- A Promising Method for the Determination of Cell Viability: The Membrane Potential Cell Viability Assay.Cells · 2022Article
- Ultraviolet light-emitting diode irradiation induces reactive oxygen species production and mitochondrial membrane potential reduction in HL-60 cells.The Journal of international medical research · 2021Article
- Conjugated linoleic acid prompts bone formation in ovariectomized osteoporotic rats and weakens osteoclast formation after treatment with ultraviolet B.Annals of translational medicine · 2021Article
- Pathogen reduction with riboflavin and ultraviolet light induces a quasi-apoptotic state in blood leukocytes.Transfusion · 2019Article
- [Effect of ultraviolet irradiation on the proliferation of acute promyelocytic leukemia cells under hypoxic conditions and related mechanisms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Protective Effects ofInternational journal of molecular sciences · 2018Article
- Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts.PloS one · 2017Article
- Ultraviolet light-emitting diode irradiation-induced cell death in HL-60 human leukemia cells in vitro.Molecular medicine reports · 2016Article
- Utilizing the virus-induced blocking of apoptosis in an easy baculovirus titration method.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet B (UVB) radiation acts as a strong apoptotic trigger in many cell types, in tumor and normal cells. Several studies have demonstrated that UVB-induced cell death occurs through the generation of reactive oxygen species. The consequent oxidative stress includes the impairment of cellular antioxidants, the induction of DNA damage and the occurrence of apoptosis. In this review, we investigated UVB apoptotic action in various cell models by using ultrastructural, molecular and cytofluorimetric techniques. Myeloid leukemia HL-60, T-lymphoblastoid Molt-4 and myelomonocytic U937 human cells, generally affected by apoptotic stimuli, were studied. Human chondrocytes and C2C12 skeletal muscle cells, known to be more resistant to damage, were also considered. All of them, when exposed to UVB radiation, revealed a number of characteristic apoptotic markers. Membrane blebbing, cytoplasm shrinkage and chromatin condensation were detected by means of electron microscopy. DNA cleavage, investigated by using agarose gel electrophoresis and TUNEL reaction, was observed in suspended cells. Differently, in chondrocytes and in skeletal muscle cells, oligonucleosomic DNA fragmentation did not appear, even if a certain TUNEL positivity was detected. These findings demonstrate that UVB radiation appears to be an ideal tool to study the apoptotic behavior.
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