ArticleGenes & development2013
Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells.
Article in Genes & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Epigenetic memory as crucial contributing factor in directing the differentiation of human iPSC into pancreatic β-cells in vitro.Cell and tissue research · 2025Review
- Post translational modification regulation of transcription factors governing pancreatic β-cell identity and functional mass.Frontiers in endocrinology · 2025Review
- Editorial: Polycomb group (PcG) proteins in development and disease.Frontiers in cell and developmental biology · 2024Article
- Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors.Communications biology · 2023Article
- Polycomb Repressive Complexes: Shaping Pancreatic Beta-Cell Destiny in Development and Metabolic Disease.Frontiers in cell and developmental biology · 2022Review
- REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.Genes & development · 2021Article
- Monogenic Diabetes Modeling:Frontiers in endocrinology · 2021Review
- Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity.Diabetologia · 2020Review
- The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.Cell metabolism · 2018Article
- How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?PloS one · 2017Article
- Article
- DNA methylation directs functional maturation of pancreatic β cells.The Journal of clinical investigation · 2015Article
- Epigenetic programming of glucose-regulated insulin release.The Journal of clinical investigation · 2015Article
- DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Epigenetic modifications and long noncoding RNAs influence pancreas development and function.Trends in genetics : TIG · 2015Review
- Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.The EMBO journal · 2014Article
- Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.Nature genetics · 2014Article
- Epigenetic regulation of pancreatic islets.Current diabetes reports · 2013Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Polycomb-mediated gene repression is essential for embryonic development, yet its precise role in lineage-specific programming is poorly understood. Here we inactivated Ring1b, encoding a polycomb-repressive complex 1 subunit, in pancreatic multipotent progenitors (Ring1b(progKO)). This caused transcriptional derepression of a subset of direct Ring1b target genes in differentiated pancreatic islet cells. Unexpectedly, Ring1b inactivation in differentiated islet β cells (Ring1b(βKO)) did not cause derepression, even after multiple rounds of cell division, suggesting a role for Ring1b in the establishment but not the maintenance of repression. Consistent with this notion, derepression in Ring1b(progKO) islets occurred preferentially in genes that were targeted de novo by Ring1b during pancreas development. The results support a model in which Ring1b bookmarks its target genes during embryonic development, and these genes are maintained in a repressed state through Ring1b-independent mechanisms in terminally differentiated cells. This work provides novel insights into how epigenetic mechanisms contribute to shaping the transcriptional identity of differentiated lineages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.