Evidence map›Paper›PMID 23271330›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2013

A behavioral task predicts conversion to mild cognitive impairment and Alzheimer's disease.

Stuart M Zola, C M Manzanares, P Clopton, J J Lah, A I Levey

Abstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Development of an Objective Autism Risk Index Using Remote Eye Tracking.Journal of the American Academy of Child and Adolescent Psychiatry · 2016
    Trial
  3. Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Eye Tracking as a Tool for Detecting Alzheimer's Disease in People With Down Syndrome.Journal of intellectual disability research : JIDR · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stuart M ZolaYerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. szola@rmy.emory.edu
C M Manzanares
P Clopton
J J Lah
A I Levey

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2005 to 2019
$25.7M
NCRR NIH HHS P51 RR000165NCRR NIH HHS RR000165NIA NIH HHS AG 025688NIA NIH HHS P50 AG025688NIH HHS P51 OD011132NIH HHS P51OD11132
6 · The paper itself

Abstract

background/rationaleCurrently, we cannot reliably differentiate individuals at risk of cognitive decline, for example, mild cognitive impairment (MCI), Alzheimer's disease (AD), from those individuals who are not at risk.

methodsA total of 32 participants with MCI and 60 control (CON) participants were tested on an innovative, sensitive behavioral assay, the visual paired comparison (VPC) task using infrared eye tracking. The participants were followed for 3 years after testing.

resultsScores on the VPC task predicted, up to 3 years prior to a change in clinical diagnosis, those patients with MCI who would and who would not progress to AD and CON participants who would and would not progress to MCI.

conclusionsThe present findings show that the VPC task can predict impending cognitive decline. To our knowledge, this is the first behavioral task that can identify CON participants who will develop MCI or patients with MCI who will develop AD within the next few years.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCognitive DysfunctionDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsRisk Assessment

Identifiers

PMID23271330
PMCPMC3670591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.