Evidence map›Paper›PMID 23271193›Full record

ArticlePsychopharmacology2013

The drug effects questionnaire: psychometric support across three drug types.

Meghan E Morean, Harriet de Wit, Andrea C King, Mehmet Sofuoglu, Sandra Y Rueger, Stephanie S O'Malley

3 registry-linked trialsAbstract readControlled Clinical Trial
In one paragraph

Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 189 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05639712 phase4completednot on this mapstarted 2022, after this paper: background citation

Understanding Opioid Use Before and After Surgery in Norway: A Prospective Multicenter Study and Randomized Double-blind Controlled Study

TypeinterventionalSponsorOslo University HospitalRan2022 to 2025Enrolled1,020ConditionsOpioid Use, Affective SymptomsArmsPlacebo, Morphine 2.5 mg i.v., Morphine 5 mg i.v., Morphine 10 mg i.v., Oxycodone 2.5 mg i.v.
NCT06544291 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Combination of THC and CBD as Novel Treatment for Co-Occurring Opioid Use Disorder and Chronic Pain

TypeinterventionalSponsorYale UniversityRan2024 to 2028Enrolled147ConditionsChronic Pain, Opioid Use DisorderArmsCBD 300mg, CBD 600mg, Placebo 0mg
NCT06822569 narecruitingnot on this mapstarted 2024, after this paper: background citation

Teen Health Choices & Wellness

TypeinterventionalSponsorBrown UniversityRan2024 to 2028Enrolled224ConditionsHealth Behavior, Wellness, Psychological, Substance UseArmsCue reactivity paradigm
3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Connectome-based encoding of subjective drug responses to acute oral methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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  14. Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meghan E MoreanDepartment of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Office S-229, 34 Park Street, New Haven, CT 06519, USA. meghan.morean@yale.edu
Harriet de Wit
Andrea C King
Mehmet Sofuoglu
Sandra Y Rueger
Stephanie S O'Malley

Funding

Alcohol Stimulation and Sedation in Binge Drinkers - Renewal 01R01AA013746 · NIAAA · UNIVERSITY OF CHICAGO · PI DANIEL J FRIDBERG, ANDREA C KING · 2003 to 2026
$11.6M
Determinants of Drug Preference in Humans--Administrative SupplementR01DA002812 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 1985 to 2024
$10.6M
Human Laboratory Studies for Stimulant AddictionK02DA021304 · NIDA · YALE UNIVERSITY · PI SOFUOGLU, MEHMET · 2008 to 2011
$460k
NIAAA NIH HHS R01 AA013746NIAAA NIH HHS R01-AA013746NIAAA NIH HHS R01-AA013746-S1NIDA NIH HHS DA02812NIDA NIH HHS K02 DA021304NIDA NIH HHS K02-DA-021304NIDA NIH HHS R01 DA002812
6 · The paper itself

Abstract

rationaleThe Drug Effects Questionnaire (DEQ) is widely used in studies of acute subjective response (SR) to a variety of substances, but the format of the DEQ varies widely across studies, and details of its psychometric properties are lacking. Thus, the field would benefit from demonstrating the reliability and validity of the DEQ for use across multiple substances.

objectiveThe current study evaluated the psychometric properties of several variations of DEQ items, which assessed the extent to which participants (1) feel any substance effect(s), (2) feel high, (3) like the effects, (4) dislike the effects, and (5) want more of the substance using 100-mm visual analog scales.

methodsDEQ data from three placebo-controlled studies were analyzed to examine SR to amphetamine, nicotine, and alcohol. We evaluated the internal structure of the DEQ for use with each substance as well as relationships between scale items, measures of similar constructs, and substance-related behaviors.

resultsResults provided preliminary psychometric support for items assessing each DEQ construct (feel, high, dislike, like, and more).

conclusionsBased on the study results, we identify several common limitations of extant variants of the DEQ and recommend an improved version of the measure. The simplicity and brevity of the DEQ combined with its promising psychometric properties support its use in future SR research across a variety of substances.

Indexed as

AdultAmphetamineDatabases, FactualEthanolFemaleHumansMaleMiddle AgedNicotinePsychometricsReproducibility of ResultsSurveys and QuestionnairesYoung AdultAmphetamineEthanolNicotine

Identifiers

PMID23271193
PMCPMC3624068

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.