ArticlePsychopharmacology2013
Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- GABAergic compounds for the treatment of alcohol use disorder.International review of neurobiology · 2024Review
- Oral Cannabidiol does not alter Alcohol Seeking and Self-Administration in Baboons.Drug and alcohol dependence · 2023Article
- Valium without dependence? Individual GABANeuropsychiatric disease and treatment · 2018Review
- Short-term and long-term effects of diazepam on the memory for discrimination and generalization of scopolamine.Psychopharmacology · 2017Article
- Pre-Clinical Studies with D-Penicillamine as a Novel Pharmacological Strategy to Treat Alcoholism: Updated Evidences.Frontiers in behavioral neuroscience · 2017Review
- Effects of the benzodiazepine GABADrug and alcohol dependence · 2017Article
- Early life stress is a risk factor for excessive alcohol drinking and impulsivity in adults and is mediated via a CRF/GABA(A) mechanism.Stress (Amsterdam, Netherlands) · 2016Article
- Role of ethanol-derived acetaldehyde in operant oral self-administration of ethanol in rats.Psychopharmacology · 2015Article
- A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model.International journal of medicinal chemistry · 2015Review
- Little evidence of a role for the α1GABAA subunit-containing receptor in a rhesus monkey model of alcohol drinking.Alcoholism, clinical and experimental research · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleThe various α subtypes of GABAA receptors have been strongly implicated in alcohol reinforcement and consumption.
objectivesThe effects of the GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on seeking and self-administration responses were evaluated in two groups of baboons trained under a 3-component chained schedule of reinforcement (CSR).
methodsAlcohol (4 % w/v; n = 5; alcohol group) or a preferred nonalcoholic beverage (n = 4; control group) was available for self-administration only in component 3 of the CSR. Responses in component 2 provided indices of motivation to drink (seeking). 3-PBC (1.0-30.0 mg/kg) and saline were administered before drinking sessions under both acute and 5-day dosing conditions.
resultsRepeated, and not acute, doses of 3-PBC significantly decreased total self-administration responses (p < 0.05), volume consumed (p < 0.05), and gram per kilogram of alcohol (p < 0.05) in the alcohol group. In the control group, 5-day administration of 3-PBC significantly decreased total self-administration responses (p < 0.05) but produced nonsignificant decreases in volume consumed. Within-session pattern of drinking was characterized by a high level of drinking in the first 20 min of the session for both groups, which was significantly (p < 0.05) decreased by all doses of 3-PBC (1.0-18.0 mg/kg) only in the alcohol group. In contrast, the first drinking bout in the control group was only reduced at the highest doses of 3-PBC (10.0 and 18.0 mg/kg).
conclusionsThe results support the involvement of the GABAA α1 subtype receptor in alcohol reinforcement and consumption.
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