ArticleMolecular biology reports2013
Polymorphism in vitamin D receptor and osteoprotegerin genes in Egyptian rheumatoid arthritis patients with and without osteoporosis.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- Vitamin D receptor (VDR) gene polymorphism and risk of rheumatoid arthritis (RA): systematic review and meta-analysis.Clinical rheumatology · 2020Pooled it
- The association between RANK, RANKL and OPG gene polymorphisms and the risk of rheumatoid arthritis: a case-controlled study and meta-analysis.Bioscience reports · 2019Pooled it
- Lack of association between vitamin D receptor polymorphisms ApaI (rs7975232) and BsmI (rs1544410) and osteoporosis among the Han Chinese population: A meta-analysis.The Kaohsiung journal of medical sciences · 2016Pooled it
- Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis : A meta-analysis.Zeitschrift fur Rheumatologie · 2016Pooled it
- Vitamin D Receptor Polymorphisms and Rheumatoid Arthritis Risk: A Systematic Review and Meta-Analysis Evaluating the Moderating Effects of Ethnicity, Bone Erosion, and Classification Criteria.Archives of rheumatology · 2026Article
- Article
- Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis.Current osteoporosis reports · 2024Review
- The impact of genetic variants related to vitamin D and autoimmunity: A systematic review.Heliyon · 2024Article
- Osteoprotegerin Gene as a Biomarker in the Development of Osteoporosis in Postmenopausal Women.Biomedicines · 2023Article
- Association betweenFrontiers in genetics · 2022Article
- Genetic and expression deregulation of immunoregulatory genes in rheumatoid arthritis.Molecular biology reports · 2021Article
- A novel quantitative method for estimating bone mineral density using B-mode ultrasound and radiofrequency signals-a pilot study on patients with rheumatoid arthritis.Experimental and therapeutic medicine · 2019Article
- Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response.BioMed research international · 2019Review
- Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development.BioMed research international · 2019Article
- Vitamin D receptor polymorphisms and expression profile in rheumatoid arthritis Brazilian patients.Molecular biology reports · 2016Article
- Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis.PloS one · 2015Article
- The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women.Disease markers · 2015Article
- Osteoporosis biomarkers act as predictors for diagnosis of chronic renal insufficiency in elder patients.International journal of clinical and experimental medicine · 2015Article
- Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report.Journal of immunology research · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1α,25-Dihydroxyvitamin D3 upregulates the expression of the receptor activator of nuclear factor kB ligand (RANKL), and downregulates osteoprotegerin (OPG) expression. We tested the effects of polymorphisms in the vitamin D receptor gene (VDR), and OPG gene in rheumatoid arthritis (RA) patients and healthy controls and their relationship to bone mineral density (BMD) and development of osteoporosis. Three hundred and fifty women were evaluated, 200 women having RA and 150 healthy control. The subjects were genotyped for polymorphism at BsmI in VDR and A163G in OPG genes by polymerase chain reaction followed by restriction fragment length polymorphism analysis. BMD was also measured. In A163G, the G allele increased the risk for RA and for the development of osteoporosis. We found a significant association between lower hip (BMD-h) and genotype variants of VDR (BsmI) and OPG A163G in RA patients with osteoporosis. Our results suggested that OPG A163G polymorphism was associated with RA susceptibility and with the development of osteoporosis in these patients. Also, VDR and OPG genes are important candidates for osteoporosis in RA patients.
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