ArticleBioorganic & medicinal chemistry letters2013
Carbon-11 N-methyl alkylation of L-368,899 and in vivo PET imaging investigations for neural oxytocin receptors.
Article in Bioorganic & medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies.Journal of psychiatry & neuroscience : JPN · 2015Pooled it
- Development and characterisation of novel oxytocin analogues for PET imaging.Communications chemistry · 2025Article
- Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote (Comparative medicine · 2024Article
- Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles.Autonomic neuroscience : basic & clinical · 2022Article
- Using Receptor Autoradiography to Visualize and Quantify Oxytocin and Vasopressin 1a Receptors in the Human and Nonhuman Primate Brain.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Chronic Intranasal Oxytocin has Dose-dependent Effects on Central Oxytocin and Vasopressin Systems in Prairie Voles (Microtus ochrogaster).Neuroscience · 2018Article
- Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem.Social neuroscience · 2017Article
- An evaluation of central penetration from a peripherally administered oxytocin receptor selective antagonist in nonhuman primates.Bioorganic & medicinal chemistry · 2017Article
- Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys.Bioorganic & medicinal chemistry letters · 2016Article
- Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications.Journal of neuroendocrinology · 2016Review
- The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders.Molecular psychiatry · 2016Review
- Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits.Frontiers in neuroscience · 2015Review
- Investigation of an F-18 oxytocin receptor selective ligand via PET imaging.Bioorganic & medicinal chemistry letters · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Compound L-368,899 was successfully alkylated with [(11)C]iodomethane to generate the oxytocin receptor selective (2R)-2-amino-N-((2S)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-N-[(11)C]methyl-3-(methylsulfonyl)propanamide ([(11)C]1) with very high radiochemical purity and high specific activity. PET imaging studies were performed with [(11)C]1 to investigate brain penetration and oxytocin receptor uptake using rat and cynomolgus monkey models. For rat baseline scans, brain penetration was observed with [(11)C]1, but no specific uptake could be distinguished in the brain region. By administering a peptide oxytocin receptor selective antagonist for peripheral blocking of oxytocin receptors, the uptake of [(11)C]1 was amplified in the rat brain temporarily to enable some visual uptake within the rat brain. A baseline scan of [(11)C]1 in a cynomolgus monkey model resulted in no detectable specific uptake in anticipated regions, but activity did accumulate in the choroid plexus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.